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http://www.guinnessworldrecords.com/world-records/fastest-half-marathon-barefoot-on-icesnow.

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M. Kox, L. T. van Eijk, J. Zwaag, J. van den Wildenberg, F. C. Sweep, J. G. van der Hoeven, and P. Pickkers, Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. Proceedings of the National Academy of Sciences of the United States of America 111, no. 20 (May 2014): 73797384.

5

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6

The Canadian Medical Hall of Fame http://cdnmedhall.org/inductees/dr-hans-selye.

7

H. Selye, The Stress of Life (New York: McGraw-Hill, 1956).

8

B. S. McEwen, Stressed or Stressed Out: What is the Difference? Journal of Psychiatry and Neuroscience 30, no. 5 (2005): 315318.

9

Peter Sterling, Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology and Rational Therapeutics. in J. Schulkin, ed., Allostasis, Homeostasis, and the Costs of Adaptation, (Cambridge University Press, 2004).

10

cyopeceoc aooecoe cocoe, p oopo cea ocycye yceoc eo cyy, oea a pey ypo o po, a ae yacy oe poecca opa.

11

A. Etkin, T. Egner, D. M. Peraza, E. R. Kandel, and J. Hirsch, Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 51, no. 6 (Sept. 2006): 871882.

12

A. Golkar, E. Johansson, M. Kasahara, W. Osika, A. Perski, and I. Savic, The Influence of Work-related Chronic Stress on the Regulation of Emotion and on Functional Connectivity in the Brain. PLoS ONE9, no. 9 (Sept. 2014): e104550.

13

N. Sadeh, J. M. Spielberg, M. W. Miller, W. P. Milberg, D. H. Salat, M. M. Amick, C. B. Fortier, and R. E. McGlinchey. Neurobiological indicators of disinhibition in posttraumatic stress disorder. Human Brain Mapping 36, no. 8 (Aug. 2015): 30763086.

14

F. Beissner, K. Meissner, K. J. Bär, and V. Napadow, The autonomic brain: an activation likelihood estimation meta-analysis for central processing of autonomic function. Journal of Neuroscience 33, no. 25 (Jun. 2013): 1050310511.

15

V. G. Macefield, C. James, and L. A. Henderson, Identification of sites of sympathetic outflow at rest and during emotional arousal: concurrent recordings of sympathetic nerve activity and fMRI of the brain. International Journal of Psychophysiology 89, no. 3 (Sept. 2013): 451459.

16

A. F. Arnsten, Stress Weakens Prefrontal Networks: Molecular Insults to Higher Cognition. Nature Neuroscience 18, no. 10 (Oct. 2015): 13761385, doi: 10.1038/nn.4087.

17

I. Negrón-Oyarzo, F. Aboitiz, and P. Fuentealba, Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-induced Neuropsychiatric Disorders. Neural Plasticity 2016 (2016): Article ID7539065.

18

J. J. Radley, R. M. Anderson, B. A. Hamilton, J. A. Alcock, and S. A. Romig-Martin, Chronic Stress-induced Alterations of Dendritic Spine Subtypes Predict Functional Decrements in an Hypothalamopituitary-adrenal-inhibitory Prefrontal Circuit. Journal of Neuroscience 33, no. 36 (Sept. 2013): 1437914391.

19

Y. C. Tse, I. Montoya, A. S. Wong, A. Mathieu, J. Lissemore, D. C. Lagace, and T. P. Wong, A Longitudinal Study of Stress-induced Hippocampal Volume Changes in Mice That Are Susceptible or Resilient to Chronic Social Defeat. Hippocampus 24, no. 9 (Sept. 2014): 11201128.

20

A. Starčević, I. Dimitrijević, M. Aksić, L. Stijak, V. Radonjić, D. Aleksić, and B. Filipović, Brain Changes in Patients with Posttraumatic Stress Disorder and Associated Alcoholism: MRI Based Study. Psychiatria Danubina 27, no. 1 (Mar. 2015): 7883.

21

L. H. Rubin, V. J. Meyer, R. J. Conant, E. E. Sundermann, M. Wu, K. M. Weber, M. H. Cohen, D. M. Little, and P. M. Maki, Prefrontal Cortical Volume Loss is Associated with Stress-related Deficits in Verbal Learning and Memory in HIV-infected Women. Neurobiology of Disease (Sept. 2015), pii: S09699961(15)300565.

22

A. Vyas, R. Mitra, B. S. Shankaranarayana Rao, and S. Chattarji, Chronic Stress Induces Contrasting Patterns of Dendritic Remodeling in Hippocampal and Amygdaloid Neurons. Journal of Neuroscience 22 (2002): 68106818.

23

G. L. Moreno, J. Bruss, and N. L. Denburg, Increased Perceived Stress is Related to Decreased Prefrontal Cortex Volumes among Older Adults. Journal of Clinical and Experimental Neuropsychology (Sept. 2016): 113.

24

W. C. Drevets, Neuroimaging and Neuropathological Studies of Depression: Implications for the Cognitive-Emotional Features of Mood Disorders. Current Opinion in Neurobiology 11 (2001): 240249.

25

G. Seravalle and G. Grassi, Sympathetic Nervous System, Hypertension, Obesity and Metabolic Syndrome. High Blood Pressure & Cardiovascular Prevention 23, no. 3 (Sept. 2016): 175179.

26

B. M. Egan, Insulin Resistance and the Sympathetic Nervous System. Current Hypertension Reports 5, no. 3 (Jun. 2003): 247254.

27

V. Zotev, R. Phillips, K. D. Young, W. C. Drevets, and J. Bodurka, Prefrontal Control of the Amygdala During Real-time fMRI Neurofeedback Training of Emotion Regulation. PLoS ONE8 (2013): e79184.

28

E. Fuchs, G. Flugge, and B. Czeh, Remodeling of Neuronal Networks by Stress. Frontiers in Bioscience 1, no. 11 (Sept. 2006): 27462758.

29

R. S. Duman, Pathophysiology of Depression and Innovative Treatments: Remodeling Glutamatergic Synaptic Connections. Dialogues in Clinical Neuroscience 16, no. 1 (Mar. 2014): 1127.

30

S. L. Christiansen, K. Højgaard, O. Wiborg, and E. V. Bouzinova EV, Disturbed Diurnal Rhythm of Three Classical Phase Markers in the Chronic Mild Stress Rat Model of Depression. Neuroscience Research 110 (Sept. 2016): 4348.

31

Y. Wu, L. Dissing-Olesen, B. A. MacVicar, and B. Stevens, Microglia: Dynamic Mediators of Synapse Development and Plasticity. Trends in Immunology 36, no. 10 (2015): 605613.

32

A. Kleinridders, H. A. Ferris, W. Cai, and C. R. Kahn, Insulin Action in Brain Regulates Systemic Metabolism and Brain Function. Diabetes 63, no. 7 (Jul. 2014): 22322243.

33

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34

A. J. Loonen and S. A. Ivanova, Circuits Regulating Pleasure and Happiness-Mechanisms of Depression. Frontiers in Human Neuroscience 10, no. 10 (Nov. 2016): 571.

35

Brian M. Galla and Jeffrey J. Wood, Trait Self-Control Predicts Adolescents Exposure and Reactivity to Daily Stressful Events. Journal of Personality 83, no. 1 (Feb. 2015): 6983.

36

T. D. Wager, M. L. Davidson, B. L. Hughes, M. A. Lindquist, and K. N. Ochsner, Prefrontal-subcortical Pathways Mediating Successful Emotional Regulation. Neuron 59 (2008): 10371050.

37

E. Blix, A. Perski, H. Berglund, and I. Savic, Long-term Occupational Stress is Associated with Regional Reductions in Brain Tissue Volumes. PLoS ONE8 (2013): e64065.

38

M. Koenigs, E. D. Huey, M. Calamia, V. Raymont, D. Tranel, and J. Grafman, Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression. Journal of Neuroscience 28 (2008): 1234112348.

39

T. S. Ligeza, M. Wyczesany, A. D. Tymorek, and M. Kamiński, Interactions between the Prefrontal Cortex and Attentional Systems during Volitional Affective Regulation: An Effective Connectivity Reappraisal Study. Brain Topography 29, no. 2 (Mar. 2016): 253261.

40

G. Sheppes and Z. Levin, Emotion Regulation Choice: Selecting between Cognitive Regulation Strategies to Control Emotion. Frontiers in Human Neuroscience 7 (2013): 179.

41

R. B. Price, B. Paul, W. Schneider, and G. J. Siegle, Neural Correlates of Three Neurocognitive Intervention Strategies: A Preliminary Step Towards Personalized Treatment for Psychological Disorders. Cognitive Therapy and Research 37, no. 4 (2013): 657672.

42

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43

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44

M. Csíkszentmihályi and J. LeFevre, Optimal Experience in Work and Leisure. Journal of Personality and Social Psychology 56, no. 5 (May 1989): 815822.

45

A. Manna, A. Raffone, M. G. Perrucci, D. Nardo, A. Ferretti, A. Tartaro, A. Londei, C. Del Gratta, M. O. Belardinelli, and G. L. Romani, Neural Correlates of Focused Attention and Cognitive Monitoring in Meditation. Brain Research Bulletin 82, nos. 12 (Apr. 2010): 4656.

46

R. Nouchi, Y. Taki, H. Takeuchi, H. Hashizume, T. Nozawa, T. Kambara, A. Sekiguchi, C. M. Miyauchi, Y. Kotozaki, H. Nouchi, and R. Kawashima, Brain Training Game Boosts Executive Functions, Working Memory and Processing Speed in the Young Adults: A Randomized Controlled Trial. PLoS ONE8, no. 2 (2013): e55518.

47

M. Muraven, R. F. Baumeister, and D. M. Tice, Longitudinal Improvement of Self-regulation through Practise: Building Self-control through Repeated Exercise. Journal of Social Psychology 139 (1999): 446457.

48

M. Muraven, Practicing Self-control Lowers the Risk of Smoking Lapse. Psychology of Addictive Behaviors 24 (2010): 446452.

49

M. Sakaki, H. J. Yoo, L. Nga, T. H. Lee, J. F. Thayer, and M. Mather, Heart Rate Variability is Associated with Amygdala Functional Connectivity with MPFC across Younger and Older Adults. Neuroimage 31, no.139 (May 2016): 4452.

50

J. F. Thayer, A. L. Hansen, E. Saus-Rose, and B. H. Johnsen, Heart Rate Variability, Prefrontal Neural Function, and Cognitive Performance: The Neurovisceral Integration Perspective on Self-regulation, Adaptation, and Health. Annals of Behavioral Medicine 37, no. 2 (Apr. 2009): 141153.

51

S. C. Segerstrom and L. S. Nes, Heart Rate Variability Reflects Selfregulatory Strength, Effort, and Fatigue. Psychological Science 18, no. 3 (Mar. 2007): 275281.

52

T. F. Heatherton and D. D. Wagner, Cognitive Neuroscience of Selfregulation Failure. Trends in Cognitive Sciences 15, no. 3 (Mar. 2011): 132139.

53

P. Bermudez et al., Neuroanatomical Correlates of Musicianship as Revealed by Cortical Thickness and Voxel-based Morphometry. Cerebral Cortex 19 (2009): 15831596.

54

K. Houben, F. C. Dassen, and A. Jansen, Taking Control: Working Memory Training in Overweight Individuals Increases Self-regulation of Food Intake. Appetite 105 (Oct. 2016): 567574.

55

J. Cranwell, S. Benford, R. J. Houghton, M. Golembewksi, J. E. Fischer, and M. S. Hagger, Increasing Self-Regulatory Energy Using an Internetbased Training Application Delivered by Smartphone Technology. Cyberpsychology, Behavior and Social Networking 17, no. 3 (2014): 181186.

56

M. H. Ashcraft and E. P. Kirk, The Relationships among Working Memory, Math Anxiety, and Performance. Journal of Experimental Psychology: General 130 (2001): 224237.

57

C. B. Young, S. S. Wu, and V. Menon, The Neurodevelopmental Basis of Math Anxiety. Psychological Science 23 (2012): 492501.

58

I. M. Lyons and S. L. Beilock, When Math Hurts: Math Anxiety Predicts Pain Network Activation in Anticipation of Doing Math. PLoS ONE7 (2012a): e48076.

59

A. Sarkar, A. Dowker, and R. Cohen Kadosh, Cognitive Enhancement or Cognitive Cost: Trait-Specific Outcomes of Brain Stimulation in the Case of Mathematics Anxiety. Journal of Neuroscience 34.50 (2014): 1660516610.

60

B. J. Casey, L. H. Somerville, I. H. Gotlib, O. Ayduk, N. T. Franklin, M. K. Askren, J. Jonides, M. G. Berman, N. L. Wilson, T. Teslovich, G. Glover, V. Zayas, W. Mischel, and Y. Shoda, Behavioral and Neural Correlates of Delay of Gratification 40 Years Later. Proceedings of the National Academy of Sciences of the United States of America 108, no. 36 (Sept. 2011): 1499815003.

61

T. P. Alloway and J. C. Horton, Does Working Memory Mediate the Link Between Dispositional Optimism and Depressive Symptoms? Applied Cognitive Psychology 30, no. 6 (Nov./Dec. 2016): 10681072.

62

A. Curci, T. Lanciano, E. Soleti, and B. Rimé, Negative Emotional Experiences Arouse Rumination and Affect Working Memory Capacity. Emotion 13, no. 5 (Oct. 2013): 867880.

63

L. Xiu, R. Zhou, and Y. Jiang, Working Memory Training Improves Emotion Regulation Ability: Evidence from HRV. Physiology & Behavior 155 (Dec. 2015): 2529.

64

S. Kühn, T. Gleich, R. C. Lorenz, U. Lindenberger, and J. Gallinat, Playing Super Mario Induces Structural Brain Plasticity: Gray Matter Changes Resulting from Training with a Commercial Video Game. Molecular Psychiatry 19, no. 2 (Feb. 2014): 265271.

65

T. S. Ligeza, M. Wyczesany, A. D. Tymorek, and M. Kamiński, Interactions between the Prefrontal Cortex and Attentional Systems during Volitional Affective Regulation: An Effective Connectivity Reappraisal Study. Brain Topography 29, no. 2 (Mar. 2016): 253261.

66

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67

C. A. Ray, and K. M. Hume, Neck Afferents and Muscle Sympathetic Activity in Humans: Implications for the Vestibulosympathetic Reflex. Journal of Applied Physiology (1985) 84, no. 2 (Feb. 1998): 450453.

68

J. C. Geinas, K. R. Marsden, Y. C. Tzeng, J. D. Smirl, K. J. Smith, C. K. Willie, N. C. Lewis, G. Binsted, D. M. Bailey, A. Bakker, T. A. Day, and P. N. Ainslie, Influence of Posture on the Regulation of Cerebral Perfusion. Aviation, Space, and Environmental Medicine 83, no. 8 (Aug. 2012): 751757.

69

L. A. Uebelacker, G. Epstein-Lubow, B. A. Gaudiano, G. Tremont, C. L. Battle, and I. W. Miller, Hatha Yoga for Depression: Critical Review of the Evidence for Efficacy, Plausible Mechanisms of Action, and Directions for Future Research. Journal of Psychiatric Practice 16, no. 1 (Jan. 2010): 2233.

70

Alain, Propos sur le bonheur. Gallimard, Folio Essais 21 (1928): 1113.

71

J. A. Robinson and K. L. Swanson, Field and Observer Modes of Remembering. Memory 1, no. 3 (Sept. 1993): 169184.

72

K. E. Gilbert, S. Nolen-Hoeksema, and J. Gruber, Positive Emotion Dysregulation across Mood Disorders: How Amplifying versus Dampening Predicts Emotional Reactivity and Illness Course. Behaviour Research and Therapy 51, no. 11 (Nov. 2013): 736741.

73

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74

E. Watkins, Adaptive and Maladaptive Ruminative Self-focus during Emotional Processing. Behaviour Research and Therapy 42, no. 9 (Sept. 2004): 10371052.

75

J. van Lier, M. L. Moulds, and F. Raes, Abstract Why Thoughts about Success Lead to Greater Positive Generalization in Sport Participants. Frontiers in Psychology 6 (Nov. 2015): 1783.

76

F. Wang, C. Wang, Q. Yin, K. Wang, D. Li, M. Mao, C. Zhu, and Y. Huang, Reappraisal Writing Relieves Social Anxiety and May be Accompanied by Changes in Frontal Alpha Asymmetry. Frontiers in Psychology 21, no. 6 (Oct. 2015): 1604.

77

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78

R. F. Helfrich and R. T. Knight, Oscillatory Dynamics of Prefrontal Cognitive Control. Trends in Cognitive Science 20, no. 12 (Dec. 2016): 916930.

79

K. Song, M. Meng, L. Chen, K. Zhou, and H. Luo, Behavioral Oscillations in Attention: Rhythmic α Pulses Mediated Through θ Band. Journal of Neuroscience 34, no. 14 (Apr. 2014): 48374844.

80

H. S. Lee, A. Ghetti, A. Pinto-Duarte, X. Wang, G. Dziewczapolski, F. Galimi, S. Huitron-Resendiz, J. C. Piña-Crespo, A. J. Roberts, I. M. Verma, T. J. Sejnowski, and S. F. Heinemann, Astrocytes Contribute to Gamma Oscillations and Recognition Memory. Proceedings of the National Academy of Sciences of the United States of America 111, no. 32 (Aug. 2014): E33433352.

81

P. Billeke, F. Zamorano, D. Cosmelli, and F. Aboitiz, Oscillatory Brain Activity Correlates with Risk Perception and Predicts Social Decisions. Cerebral Cortex 23, no. 12 (Dec. 2013): 2872780.

82

B. Voloha, T. Valiante, S. Everling, and T. Womelsdorf, Theta-gamma Coordination between Anterior Cingulate and Prefrontal Cortex Indexes Correct Attention Shifts. Proceedings of the National Academy of Sciences of the United States of America 112, no. 27 (Jul. 2015): 84578462.

83

M. Ertl, M. Hildebrandt, K. Ourina, G. Leicht, and C. Mulert, Emotion Regulation by Cognitive Reappraisal The Role of Frontal Theta Oscillations. NeuroImage 81 (Nov. 2013): 412421.

84

R. F. Helfrich, T. R. Schneider, S. Rach, S. A. Trautmann-Lengsfeld, A. K. Engel, et al., Entrainment of Brain Oscillations by Transcranial Alternating Current Stimulation. Current Biology 24 (2014): 333339.

85

M. Bonnefond and O. Jensen, Alpha Oscillations Serve to Protect Working Memory Maintenance against Anticipated Distracters. Current Biology 22 (2012): 19691974.

86

C. F. Lavallee, S. A. Koren, and M. A. Persinger, A Quantitative Electroencephalographic Study of Meditation and Binaural Beat Entrainment. Journal of Alternative and Complementary Medicine 17, no. 4 (Apr. 2011): 351355.

87

L. Chaieb, E. C. Wilpert, T. P. Reber, and J. Fell, Auditory Beat Stimulation and its Effects on Cognition and Mood States. Frontiers in Psychiatry 6 (May 2015): 70.

88

H. Wahbeh, C. Calabrese, H. Zwickey, and D. Zajdel, Binaural Beat Technology in Humans: A Pilot Study to Assess Neuropsychologic, Physiologic, and Electroencephalographic Effects. Journal of Alternative and Complementary Medicine 13, no. 2 (Mar. 2007): 199206.

89

R. Padmanabhan, A. J. Hildreth, and D. Laws, A Prospective, Randomised, Controlled Study Examining Binaural Beat Audio and Preoperative Anxiety in Patients Undergoing General Anaesthesia for Day Case Surgery. Anaesthesia 60, no. 9 (Sept. 2005): 874877.

90

P. A. McConnell, B. Froeliger, E. L. Garland, J. C. Ives, and G. A. Sforzo, Auditory Driving of the Autonomic Nervous System: Listening to Theta-frequency Binaural Beats Post-exercise Increases Parasympathetic Activation and Sympathetic Withdrawal. Frontiers in Psychology 14, no. 5 (Nov. 2014): 1248.

91

K. Unno, K. Iguchi, N. Tanida, K. Fujitani, N. Takamori, H. Yamamoto, N. Ishii, H. Nagano, T. Nagashima, A. Hara, K. Shimoi, and M. Hoshino, Ingestion of Theanine, an Amino Acid in Tea, Suppresses Psychosocial Stress in Mice. Experimental Physiology 98, no. 1 (Jan. 2013): 290303.

92

A. L. Lardner, Neurobiological Effects of the Green Tea Constituent Theanine and its Potential Role in the Treatment of Psychiatric and Neurodegenerative Disorders. Nutritional Neuroscience 17, no. 4 (Jul. 2014): 145155.

93

D. A. Camfield, C. Stough, J. Farrimond, and A. B. Scholey, Acute Effects of Tea Constituents L-theanine, Caffeine, and Epigallocatechin Gallate on Cognitive Function and Mood: A Systematic Review and Meta-analysis. Nutrition Reviews 72, no. 8 (Aug. 2014): 507522.

94

S. Borgwardt, F. Hammann, K. Scheffler, M. Kreuter, J. Drewe, and C. Beglinger, Neural Effects of Green Tea Extract on Dorsolateral Prefrontal Cortex. European Journal of Clinical Nutrition 66, no. 11 (Nov. 2012): 11871192.

95

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96

http://www.thenational.ae/news/peacefulness-through-a-bowl-of-tea.

97

N. Skoluda, J. Strahler, W. Schlotz, L. Niederberger, S. Marques, S. Fischer, M. V. Thoma, C. Spoerri, U. Ehlert, and U. M. Nater, Intraindividual Psychological and Physiological Responses to Acute Laboratory Stressors of Different Intensity. Psychoneuroendocrinology 51 (Jan. 2015): 227236.

98

J. LeMoult and J. Joormann, Depressive Rumination Alters Cortisol Decline in Major Depressive Disorder. Biological Psychology 100 (Jul. 2014): 5055.

99

J. F. Brosschot, W. Gerin, and J. F. Thayer, Worry and Health: The Perseverative Cognition Hypothesis. Journal of Psychosomatic Research 60 (2006): 113124.

100

S. Nolen-Hoeksema, The Role of Rumination in Depressive Disorders and Mixed Anxiety/Depressive Symptoms. Journal of Abnormal Psychology 109, no. 3 (2000): 504511.

101

J. Morrow and S. Nolen-Hoeksema, Effects of Responses to Depression on the Remediation of Depressive Affect. Journal of Personality and Social Psychology 58, no. 3 (1990): 519527.

102

M. Glynn, N. Christenfeld, and W. Gerin, The Role of Rumination in Recovery from Reactivity: Cardiovascular Consequences of Emotional States. Psychosomatic Medicine 64, no. 5 (2002): 714726.

103

W. Gerin, K. W. Davidson, N. J. S. Christenfeld, T. Goyal, and J. E. Schwartz, The Role of Angry Rumination and Distraction in Blood Pressure Recovery from Emotional Arousal. Psychosomatic Medicine 68 (2006): 6472.

104

B. L. Key, T. S. Campbell, S. L. Bacon, and W. Gerin, The Influence of Trait and State Rumination on Cardiovascular Recovery from a Negative Emotional Stressor. Journal of Behavioral Medicine 31 (2008): 237248.

105

D. Gianferante, M. V. Thoma, L. Hanlin, et al., Post-stress Rumination Predicts HPA Axis Responses to Repeated Acute Stress. Psychoneuroendocrinology 49 (2014): 244252, doi: 10.1016/j.psyneuen.2014.07.021.

106

R. B. Price, B. Paul, W. Schneider, and G. J. Siegle, Neural Correlates of Three Neurocognitive Intervention Strategies: A Preliminary Step Towards Personalized Treatment for Psychological Disorders. Cognitive Therapy and Research 37, no. 4 (Aug. 2013): 657672.

107

J. Skorka-Brown, J. Andrade, and J. May, Playing Tetris Reduces the Strength, Frequency and Vividness of Naturally Occurring Cravings. Appetite 76 (May 2014): 161165.

108

E. E. Hill, E. Zack, C. Battaglini, M. Viru, A. Viru, and A. C. Hackney, Exercise and Circulating Cortisol Levels: The Intensity Threshold Effect. Journal of Endocrinological Investigation 31, no. 7 (Jul. 2008): 587591.

109

E. Puterman, A. ODonovan, N. E. Adler, A. J. Tomiyama, M. Kemeny, O. M. Wolkowitz, and E. Epel, Physical Activity Moderates Effects of Stressor-induced Rumination on Cortisol Reactivity. Psychosomatic Medicine 73, no. 7 (Sept. 2011): 604611.

110

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111

B. Oneda, K. C. Ortega, J. L. Gusmão, T. G. Araújo, and D. Mion, Jr., Sympathetic Nerve Activity is Decreased during Device-guided Slow Breathing. Hypertension Research 33, no. 7 (Jul. 2010): 708712.

112

D. Harada, H. Asanoi, J. Takagawa, H. Ishise, H. Ueno, Y. Oda, Y. Goso, S. Joho, and H. Inoue, Slow and Deep Respiration Suppresses Steady-state Sympathetic Nerve Activity in Patients with Chronic Heart Failure: From Modeling to Clinical Application. American Journal of Physiology-Heart and Circulatory Physiology 307, no. 8 (Oct. 2014): H11591168.

113

R. Padmanabhan, A. J. Hildreth, and D. Laws, A Prospective, Randomised, Controlled Study Examining Binaural Beat Audio and Pre-operative Anxiety in Patients Undergoing General Anaesthesia for Day Case Surgery. Anaesthesia 60 (2005): 874877.

114

P. A. McConnell, B. Froeliger, E. L. Garland, J. C. Ives, and G. A. Sforzo, Auditory Driving of the Autonomic Nervous System: Listening to Theta-frequency Binaural Beats Post-exercise Increases Parasympathetic Activation and Sympathetic Withdrawal. Frontiers in Psychology 14, no. 5 (Nov. 2014): 1248.

115

B. Gingras, G. Pohler, and W. T. Fitch, Exploring Shamanic Journeying: Repetitive Drumming with Shamanic Instructions Induces Specific Subjective Experiences but No Larger Cortisol Decrease Than Instrumental Meditation Music. PLoS ONE9, no. 7 (Jul. 2014): e102103.

116

E. Largo-Wight, B. K. OHara, and W. W. Chen, The Efficacy of a Brief Nature Sound Intervention on Muscle Tension, Pulse Rate, and Self-reported Stress: Nature Contact Micro-break in an Office or Waiting Room. HERD10, no. 1 (Oct. 2016): 4551.

117

M. Annerstedt, P. Jönsson, M. Wallergård, G. Johansson, B. Karlson, P. Grahn, A. M. Hansen, and P. Währborg, Inducing Physiological Stress Recovery with Sounds of Nature in a Virtual Reality Forest Results from a Pilot Study. Physiology & Behavior 118 (Jun. 2013): 240250.

118

D. K. Brown, J. L. Barton, and V. F. Gladwell, Viewing Nature Scenes Positively Affects Recovery of Autonomic Function Following Acute-Mental Stress. Environmental Science & Technology 47, no. 11 (2013): 55625569.

119

V. F. Gladwell, D. K. Brown, J. L. Barton, M. P. Tarvainen, P. Kuoppa, J. Pretty, J. M. Suddaby, and G. R. Sandercock, The Effects of Views of Nature on Autonomic Control. European Journal of Applied Physiology 112, no. 9 (Sept. 2012): 33793386.

120

S. Dong and T. J. Jacob, Combined Non-adaptive Light and Smell Stimuli Lowered Blood Pressure, Reduced Heart Rate and Reduced Negative Affect. Physiology & Behavior 156 (Mar. 2016): 94105.

121

M. J. Henckens, G. A. van Wingen, M. Joels, and G. Fernandez, Time-dependent Corticosteroid Modulation of Prefrontal Working Memory Processing. Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 58015806.

122

K. Imai, H. Sato, M. Hori, H. Kusuoka, H. Ozaki, H. Yokoyama, H. Takeda, M. Inoue, and T. Kamada, Vagally Mediated Heart Rate Recovery after Exercise is Accelerated in Athletes but Blunted in Patients with Chronic Heart Failure. Journal of the American College of Cardiology 24, no. 6 (Nov. 1994): 15291535.

123

T. Otsuki, S. Maeda, M. Iemitsu, Y. Saito, Y. Tanimura, J. Sugawara, R. Ajisaka, and T. Miyauchi, Postexercise Heart Rate Recovery Accelerates in Strength-trained Athletes. Medicine & Science in Sports & Exercise 39, no. 2 (Feb. 2007): 365370.

124

M. Nakamura, K. Hayashi, K. Aizawa, N. Mesaki, and I. Kono, Effects of Regular Aerobic Exercise on Post-exercise Vagal Reactivation in Young Female. European Journal of Sport Science 13, no. 6 (2013): 674680.

125

S. Seiler, O. Haugen, and E. Kuffel, Autonomic Recovery after Exercise in Trained Athletes: Intensity and Duration Effects. Medicine & Science in Sports & Exercise 39, no. 8 (Aug. 2007): 13661373.

126

J. Sugawara, H. Murakami, S. Maeda, S. Kuno, and M. Matsuda, Change in Post-exercise Vagal Reactivation with Exercise Training and Detraining in Young Men. European Journal of Applied Physiology 85, nos. 34 (Aug. 2001): 259263.

127

U. Rimmele, R. Seiler, B. Marti, P. H. Wirtz, U. Ehlert, and M. Heinrichs, The Level of Physical Activity Affects Adrenal and Cardiovascular Reactivityto Psychosocial Stress. Psychoneuroendocrinology 34 (2009): 190198.

128

E. Zschucke, B. Renneberg, F. Dimeo, T. Wüstenberg, and A. Ströhle, The Stress-buffering Effect of Acute Exercise: Evidence for HPA Axis Negative Feedback. Psychoneuroendocrinology 51 (Jan. 2015): 414425.

129

T. Baghurst and B. C. Kelley, An examination of stress in college students over the course of a semester. Health Promotion Practice 15, no. 3 (May 2014): 438447.

130

P. Kaikkonen, A. Nummela, and H. Rusko, Heart Rate Variability Dynamics during Early Recovery after Different Endurance Exercises. European Journal of Applied Physiology 102 (2007): 7986.

131

P. Kaikkonen, H. Rusko, and K. Martinma, Post-exercise Heart Rate Variability of Endurance Athletes after Different High-intensity Exercises. Scandinavian Journal of Medicine & Science in Sports 18 (2008): 511519.

132

M. M. Tanskanen, H. Kyröläinen, A. L. Uusitalo, J. Huovinen, J. Nissilä, H. Kinnunen, M. Atalay, and K. Häkkinen, Serum Sex Hormone-binding Globulin and Cortisol Concentrations Are Associated with Overreaching during Strenuous Military Training. Journal of Strength and Conditioning Research 25, no. 3 (Mar. 2011): 787797.

133

J. L. Abelson, T. M. Erickson, S. E. Mayer, J. Crocker, H. Briggs, N. L. Lopez-Duran, and I. Liberzon, Brief Cognitive Intervention Can Modulate Neuroendocrine Stress Responses to the Trier Social Stress Test: Buffering Effects of a Compassionate Goal Orientation. Psychoneuroendocrinology 44 (Jun. 2014): 6070.

134

A. A. Mohammadi, S. Jazayeri, K. Khosravi-Darani, Z. Solati, N. Mohammadpour, Z. Asemi, Z. Adab, M. Djalali, M. Tehrani-Doost, M. Hosseini, and S. Eghtesadi, The Effects of Probiotics on Mental Health and Hypothalamic-pituitary-adrenal Axis: A Randomized, Double-blind, Placebo-controlled Trial in Petrochemical Workers. Nutritional Neuroscience 19, no. 9 (Apr. 2015): 387395.

135

T. Backes, P. Horvath, and K. Kazial, Salivary Alpha Amylase and Salivary Cortisol Response to Fluid Consumption in Exercising Athletes. Biology of Sport 32, no. 4 (2015): 275280.

136

B. R. Ely, K. J. Sollanek, S. N. Cheuvront, H. R. Lieberman, and R. W. Kenefick, Hypohydration and Acute Thermal Stress Affect Mood State but Not Cognition or Dynamic Postural Balance. European Journal of Applied Physiology 113, no. 4 (Apr. 2013): 10271034.

137

R. Micha, P. J. Rogers, and M. Nelson, Glycaemic Index and Glycaemic Load of Breakfast Predict Cognitive Function and Mood in School Children: A Randomised Controlled Trial. British Journal of Nutrition 106, no. 10 (Nov. 2011): 15521561.

138

A. R. Allen, L. R. Gullixson, S. C. Wolhart, S. L. Kost, D. R. Schroeder, and J. H. Eisenach, Dietary Sodium Influences the Effect of Mental Stress on Heart Rate Variability: A Randomized Trial in Healthy Adults. Journal of Hypertension 32, no. 2 (Feb. 2014): 374382.

139

J. B. Beekman, M. L. Stock, and T. Marcus, Need to Belong, Not Rejection Sensitivity, Moderates Cortisol Response, Self-Reported Stress, and Negative Affect Following Social Exclusion. Journal of Social Psychology 156, no. 2 (2016): 131138.

140

M. T. Bowen and I. S. McGregor, Oxytocinand Vasopressin Modulate the Social Response to Threat: A Preclinical Study. International Journal of Neuropsychopharmacology 17, no. 10 (Oct. 2014): 16211633.

141

M. Heinrichs, T. Baumgartner, C. Kirschbaum, and U. Ehlert, Social Support and Oxytocin Interact to Suppress Cortisol and Subjective Responses to Psychosocial Stress. Biological Psychiatry 54 (2003): 13891398.

142

C. Crockford, T. Deschner, T. E. Ziegler, and R. M. Wittig, Endogenous Peripheral Oxytocin Measures Can Give Insight into the Dynamics of Social Relationships: A Review. Frontiers in Behavioral Neuroscience 8 (2014): 68.

143

K. M. Grewen, S. S. Girdler, J. Amico, and K. C. Light, Effects of Partner Support on Resting Oxytocin, Cortisol, Norepinephrine, and Blood Pressure before and after Warm Partner Contact. Psychosomatic Medicine 67, no. 4 (Jul. Aug. 2005): 531538.

144

S. Ogawa, S. Kudo, Y. Kitsunai, and S. Fukuchi, Increase in Oxytocin Secretion at Ejaculation in Male. Clinical Endocrinology 13 (1980): 9597.

145

M. S. Carmichael, R. Humbert, J. Dixen, G. Palmisano, W. Greenleaf, and J. M. Davidson, Plasma Oxytocin Increases in the Human Sexual Response. Journal of Clinical Endocrinology & Metabolism 64 (1987): 2731.

146

R. A. Turner, M. Altemus, T. Enos, B. Cooper, and T. McGuinness, Preliminary Research on Plasma Oxytocin in Normal Cycling Women: Investigating Emotion and Interpersonal Distress. Psychiatry 62 (1999): 97113.

147

M. H. Rapaport, P. Schettler, and C. Bresee, A Preliminary Study of the Effects of Repeated Massage on Hypothalamic-pituitaryadrenal and Immune Function in Healthy Individuals: A Study of Mechanisms of Action and Dosage. Journal of Alternative and Complementary Medicine 18, no. 8 (Aug. 2012): 789797.

148

http://www.businessinsider.com/professional-cuddler-2014-7.

149

T. L. Kraft and S. D. Pressman, Grin and Bear It: The Influence of Manipulated Facial Expression on the Stress Response. Psychological Science 23, no. 11 (2012): 13721378.

150

S. S. Dickerson and M. E. Kemeny, Acute Stressors and Cortisol Responses: A Theoretical Integration and Synthesis of Laboratory Research. Psychological Bulletin 130 (2004): 355391.

151

Y. Yamanaka, S. Hashimoto, N. N. Takasu, Y. Tanahashi, S. Y. Nishide, S. Honma, and K. Honma, Morning and Evening Physical Exercise Differentially Regulate the Autonomic Nervous System during Nocturnal Sleep in Humans. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 309, no. 9 (Nov. 2015): R11121121.

152

S. Kuwahata, M. Miyata, S. Fujita, T. Kubozono, T. Shinsato, Y. Ikeda, S. Hamasaki, T. Kuwaki, and C. Tei, Improvement of Autonomic Nervous Activity by Waon Therapy in Patients with Chronic Heart Failure. Journal of Cardiology 57, no. 1 (Jan. 2011): 100106.

153

Y. Soejima, T. Munemoto, A. Masuda, Y. Uwatoko, M. Miyata, and C. Tei, Effects of Waon Therapy on Chronic Fatigue Syndrome: A Pilot Study. Internal Medicine 54, no. 3 (2015): 333338.

154

G. Kanji, M. Weatherall, R. Peter, G. Purdie, and R. Page, Efficacy of Regular Sauna Bathing for Chronic Tension-type Headache: A Randomized Controlled Study. Journal of Alternative and Complementary Medicine 21, no. 2 (Feb. 2015): 103109.

155

J. H. Fowler and N. A. Christakis, Dynamic Spread of Happiness in a Large Social Network: Longitudinal Analysis over 20 Years in the Framingham Heart Study. British Medical Journal 337 (Dec. 2008): a2338.

156

O. A. Coubard. An Integrative Model for the Neural Mechanism of Eye Movement Desensitization and Reprocessing (EMDR). Frontiers in Behavioral Neuroscience 10 (2016): 52.

157

https://www.youtube.com/watch?v=nylajeG6uFY. Retrieved August 5, 2016.

158

C. Acarturk, E. Konuk, M. Cetinkaya, I. Senay, M. Sijbrandij, B. Gulen, and P. Cuijpers, The Efficacy of Eye Movement Desensitization and Reprocessing for Post-traumatic Stress Disorder and Depression among Syrian Refugees: Results of a Randomized Controlled Trial. Psychological Medicine 46, no. 12 (Sept. 2016): 25832593.

159

M. Maroufi, S. Zamani, Z. Izadikhah, M. Marofi, and P. OConnor, Investigating the Effect of Eye Movement Desensitization and Reprocessing (EMDR) on Postoperative Pain Intensity in Adolescents Undergoing Surgery: A Randomized Controlled Trial. Journal of Advanced Nursing 72, no. 9 (Sept. 2016): 22072217.

160

R. N. McLay, J. A. Webb-Murphy, S. F. Fesperman, E. M. Delaney, S. K. Gerard, S. C. Roesch, B. J. Nebeker, I. Pandzic, E. A. Vishnyak, and S. L. Johnston, Outcomes from Eye Movement Desensitization and Reprocessing in Active-Duty Service Members with Posttraumatic Stress Disorder. Psychological Trauma 8, no. 6 (Mar. 2016): 702708.

161

M. Banasr, G. W. Valentine, X. Y. Li, S. L. Gourley, J. R. Taylor, and R. S. Duman, Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat. Biological Psychiatry 62, no. 5 (Sept. 2007): 496504.

162

E. Blix, A. Perski, H. Berglund, and I. Savic, Long-term Occupational Stress is Associated with Regional Reductions in Brain Tissue Volumes. PLoS ONE8, no. 6 (Jun. 2013): e64065.

163

C. D. Gipson and M. F. Olive, Structural and Functional Plasticity of Dendritic Spines Root or Result of Behavior? Genes, Brain and Behavior 2017 16, no. 1 (Jan. 2017): 101117.

164

V. Pinto, J. C. Costa, P. Morgado, C. Mota, A. Miranda, F. V. Bravo, T. G. Oliveira, J. J. Cerqueira, and N. Sousa, Differential Impact of Chronic Stress Along the Hippocampal Dorsal-ventral Axis. Brain Structure and Function 220, no. 2 (Mar. 2015): 12051212.

165

A. Ashokan, A. Hegde, and R. Mitra, Short-term Environmental Enrichment is Sufficient to Counter Stress-induced Anxiety and Associated Structural and Molecular Plasticity in Basolateral Amygdala. Psychoneuroendocrinology 69 (Jul. 2016): 189196.

166

A. N. Sharma, E. da Costa, B. F. Silva, J. C. Soares, A. F. Carvalho, and J. Quevedo, Role of Trophic Factors GDNF, IGF-1 and VEGF in Major Depressive Disorder: A Comprehensive Review of Human Studies. Journal of Affective Disorders 197 (Jun. 2016): 920.

167

M. E. Maynard, C. Chung, A. Comer, K. Nelson, J. Tran, N. Werries, E. A. Barton, M. Spinetta, and J. L. Leasure, Ambient Temperature Influences the Neural Benefits of Exercise. Behavioural Brain Research 299 (Feb. 2016): 2731.

168

N. M. Vega-Rivera, L. Ortiz-López, A. Gómez-Sánchez, J. OikawaSala, E. M. Estrada-Camarena, and G. B. Ramírez-Rodríguez, The Neurogenic Effects of an Enriched Environment and its Protection against the Behavioral Consequences of Chronic Mild Stress Persistent after Enrichment Cessation in Six-month-old Female Balb/C Mice. Behavioural Brain Research 301 (Mar. 2016): 7283.

169

E. Castilla-Ortega, C. Rosell-Valle, C. Pedraza, F. Rodríguez de Fonseca, G. Estivill-Torrús, and L. J. Santín, Voluntary Exercise Followed by Chronic Stress Strikingly Increases Mature Adult-born Hippocampal Neurons and Prevents Stress-induced Deficits in What-when-where Memory. Neurobiology of Learning and Memory 109 (Mar. 2014): 6273.

170

H. van Praag, G. Kempermann, and F. H. Gage, Running Increases Cell Proliferation and Neurogenesis in the Adult Mouse Dentate Gyrus. Nature Neuroscience 2, no. 3 (Mar. 1999): 266270.

171

S. A. Neeper, F. Gomez-Pinilla, J. Choi, and C. W. Cotman, Physical Activity Increases mRNA for Brain-derived Neurotrophic Factor and Nerve Growth Factor in Rat Brain. Brain Research 726 (1996): 4956.

172

M. S. Nokia, S. Lensu, J. P. Ahtiainen, P. P. Johansson, L. G. Koch, S. L. Britton, and H. Kainulainen, Physical Exercise Increases Adult Hippocampal Neurogenesis in Male Rats Provided it is Aerobic and Sustained. Journal of Physiology 594, no. 7 (Apr. 2016): 18551873.

173

K. Inoue, M. Okamoto, J. Shibato, M. C. Lee, T. Matsui, R. Rakwal, and H. Soya, Long-term Mild, Rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus. PLoS ONE10, no. 6 (Jun. 2015): e0128720.

174

A. Dinoff, N. Herrmann, W. Swardfager, C. S. Liu, C. Sherman, S. Chan, and K. L. Lanctôt, The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis. PLoS ONE11, no. 9 (Sept. 2016): e0163037.

175

K. I. Erickson, M. W. Voss, R. S. Prakash, C. Basak, A. Szabo, L. Chaddock, J. S. Kim, S. Heo, H. Alves, S. M. White, T. R. Wojcicki, E. Mailey, V. J. Vieira, S. A. Martin, B. D. Pence, J. A. Woods, E. McAuley, and A. F. Kramer, Exercise Training Increases Size of Hippocampus and Improves Memory. Proceedings of the National Academy of Sciences of the United States of America 108, no. 7 (Feb. 2011): 30173022.

176

C. H. Hillman, K. I. Erickson, and A. F. Kramer, Be Smart, Exercise Your Heart: Exercise Effects on Brain and Cognition. Nature Reviews Neuroscience 9, no. 1 (Jan. 2008): 5865.

177

M. Zagaar, A. Dao, A. Levine, I. Alhaider, and K. Alkadhi, Regular Exercise Prevents Sleep Deprivation Associated Impairment of Long-term Memory and Synaptic Plasticity in the CA1 Area of the Hippocampus. Sleep 36, no. 5 (May 2013): 751761.

178

T. Kobilo, Q. R. Liu, K. Gandhi, et al., Running is the Neurogenic and Neurotrophic Stimulus in Environmental Enrichment. Learning & Memory 18 (2011): 605609.

179

G. Wagner, M. Herbsleb, F. Cruz, A. Schumann, F. Brünner, C. Schachtzabel, A. Gussew, C. Puta, S. Smesny, H. W. Gabriel, J. R. Reichenbach, and K. J. Bär, Hippocampal Structure, Metabolism, and Inflammatory Response after a 6-week Intense Aerobic Exercise in Healthy Young Adults: A Controlled Trial. Journal of Cerebral Blood Flow & Metabolism 35, no. 10 (Oct. 2015): 15701578.

180

.

181

C. J. Heyser, E. Masliah, A. Samimi, I. L. Campbell, and L. H. Gold, Progressive Decline in Avoidance Learning Paralleled by Inflammatory Neurodegeneration in Transgenic Mice Expressing Interleukin 6 in the Brain. Proceedings of the National Academy of Sciences of the United States of America 94 (1997): 15001505.

182

D. L. Gruol, IL-6 Regulation of Synaptic Function in the CNS. Neuropharmacology 96 (2015): 4254, doi: 10.1016/j.neuropharm.2014.10.023.

183

M. A. Ajmone-Cat, E. Cacci, and L. Minghetti, Non Steroidal Antiinflammatory Drugs and Neurogenesis in the Adult Mammalian Brain. Current Pharmaceutical Design 14, no. 14 (2008): 14351442.

184

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185

K. Inoue, M. Okamoto, J. Shibato, M. C. Lee, T. Matsui, R. Rakwal, and H. Soya, Long-term Mild, Rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus. PLoS ONE10, no. 6 (Jun. 2015): e0128720.

186

M. E. Maynard, C. Chung, A. Comer, K. Nelson, J. Tran, N. Werries, E. A. Barton, M. Spinetta, and J. L. Leasure, Ambient Temperature Influences the Neural Benefits of Exercise. Behavioural Brain Research 299 (Feb. 2016): 2731.

187

G. Umschweif, D. Shabashov, A. G. Alexandrovich, V. Trembovler, M. Horowitz, and E. Shohami, Neuroprotection after Traumatic Brain Injury in Heat-acclimated Mice Involves Induced Neurogenesis and Activation of Angiotensin Receptor Type 2 Signaling. Journal of Cerebral Blood Flow & Metabolism 34, no. 8 (2014): 13811390.

188

V. Bhagya, B. N. Srikumar, J. Veena, and B. S. Shankaranarayana Rao, Short-term Exposure to Enriched Environment Rescues Chronic Stress-induced Impaired Hippocampal Synaptic Plasticity, Anxiety, and Memory Deficits. Journal of Neuroscience Research (Nov. 2016) (epub ahead of print), doi: 10.1002/jnr.23992.

189

T. Novkovic, T. Mittmann, and D. Manahan-Vaughan, BDNF Contributes to the Facilitation of Hippocampal Synaptic Plasticity and Learning Enabled by Environmental Enrichment. Hippocampus 25, no. 1 (Jan. 2015): 115.

190

J. Aarse, S. Herlitze, and D. Manahan-Vaughan, The Requirement of BDNF for Hippocampal Synaptic Plasticity is Experiencedependent. Hippocampus 26, no. 6 (Jun. 2016): 739751.

191

A. Ashokan, A. Hegde, and R. Mitra, Short-term Environmental Enrichment is Sufficient to Counter Stress-induced Anxiety and Associated Structural and Molecular Plasticity in Basolateral Amygdala. Psychoneuroendocrinology 69 (Jul. 2016): 189196.

192

G. D. Clemenson and C. E. L. Stark, Virtual Environmental Enrichment through Video Games Improves Hippocampal-Associated Memory. Journal of Neuroscience 35, no. 49 (Dec. 2015): 1611616125.

193

S. Seinfeld, H. Figueroa, J. Ortiz-Gil, and M. V. Sanchez-Vives, Effects of Music Learning and Piano Practice on Cognitive Function, Mood and Quality of Life in Older Adults. Frontiers in Psychology 4 (2013): 810.

194

J. Oltmanns, B. Godde, A. H. Winneke, G. Richter, C. Niemann, C. Voelcker-Rehage, K. Schömann, and U. M. Staudinger, Dont Lose Your Brain at Work The Role of Recurrent Novelty at Work in Cognitive and Brain Aging. Frontiers in Psychology 8 (2017): 117.

195

A. Arslan-Ergul, A. T. Ozdemir, and M. M. Adams, Aging, Neurogenesis, and Caloric Restriction in Different Model Organisms. Aging and Disease 4, no. 4 (Jun. 2013): 221232.

196

A. V. Witte, M. Fobker, R. Gellner, S. Knecht, and A. Floel, Caloric Restriction Improves Memory in Elderly Humans. Proceedings of the National Academy of Sciences of the United States of America 106 (2009): 12551260.

197

A. K. E. Hornsby, Y. T. Redhead, D. J. Rees, et al., Short-term Calorie Restriction Enhances Adult Hippocampal Neurogenesis and Remote Fear Memory in a Ghsr-dependent Manner. Psychoneuroendocrinology 63 (2016): 198207.

198

L. L. Hurley, L. Akinfiresoye, E. Nwulia, A. Kamiya, A. A. Kulkarni, and Y. Tizabi, Antidepressant-like Effects of Curcumin in WKY Rat Model of Depression is Associated with an Increase in Hippocampal BDNF. Behavioural Brain Research 239 (Feb. 2013): 2730.

199

D. Liu, Z. Wang, Z. Gao, K. Xie, Q. Zhang, H. Jiang, and Q. Pang, Effects of Curcumin on Learning and Memory Deficits, BDNF, and ERK Protein Expression in Rats Exposed to Chronic Unpredictable Stress. Behavioural Brain Research 271 (Sept. 2014): 116121.

200

A. L. Lopresti, M. Maes, G. L. Maker, S. D. Hood, and P. D. Drummond, Curcumin for the Treatment of Major Depression: A Randomised, Double-blind, Placebo-controlled Study. Journal of Affective Disorders 167 (2014): 368375.

201

A. L. Lopresti and P. D. Drummond, Efficacy of Curcumin, and a Saffron/Curcumin Combination for the Treatment of Major Depression: A Randomised, Double-blind, Placebo-controlled Study. Journal of Affective Disorders 207 (Jan. 2017): 188196.

202

B. B. Aggarwal, W. Yuan, S. Li, and S. C. Gupta, Curcumin-free Turmeric Exhibits Anti-inflammatory and Anticancer Activities: Identification of Novel Components of Turmeric. Molecular Nutrition & Food Research 57, no. 9 (Sept. 2013): 15291542.

203

R. W. Johnson, Feeding the Beast: Can Microglia in the Senescent Brain Be Regulated by Diet? Brain, Behavior, and Immunity 43 (Jan. 2015): 18.

204

V. Chesnokova, R. N. Pechnick, and K. Wawrowsky, Chronic Peripheral Inflammation, Hippocampal Neurogenesis, and Behavior. Brain, Behavior, and Immunity 58 (Nov. 2016): 18.

205

D. Csabai, K. Csekő, L. Szaiff, Z. Varga, A. Miseta, Z. Helyes, and B. Czéh, Low Intensity, Long Term Exposure to Tobacco Smoke Inhibits Hippocampal Neurogenesis in Adult Mice. Behavioural Brain Research 302 (Apr. 2016): 4452.

206

Y. H. Shih, S. F. Tsai, S. H. Huang, Y. T. Chiang, M. W. Hughes, S. Y. Wu, C. W. Lee, T. T. Yang, and Y. M. Kuo, Hypertension Impairs Hippocampus-related Adult Neurogenesis, CA1 Neuron Dendritic Arborization and Long-term Memory. Neuroscience 322 (Feb. 2016): 346357.

207

.

208

M. Bellesi, L. de Vivo, G. Tononi, and C. Cirelli, Effects of Sleep and Wake on Astrocytes: 896 Clues from Molecular and Ultrastructural Studies. BMC Biology 13, no. 66 (2015).

209

G. Bernardi, L. Cecchetti, F. Siclari, A. Buchmann, X. Yu, G. Handjaras, M. Bellesi, E. Ricciardi, S. R. Kecskemeti, B. A. Riedner, A. L. Alexander, R. M. Benca, M. F. Ghilardi, P. Pietrini, C. Cirelli, and G. Tononi, Sleep Reverts Changes in Human Gray and White Matter Caused by Wake-dependent Training. NeuroImage 129 (Apr. 2016): 367377.

210

A. A. Borbely, The S-deficiency Hypothesis of Depression and the Two-Process Model of Sleep Regulation. Pharmacopsychiatry 20 (1987): 2329.

211

A. Germain and M. Dretsch, Sleep and Resilience A Call for Prevention and Intervention. Sleep 39, no. 5 (2016): 963965.

212

M. M. Menz, J. S. Rihm, and C. Büchel, REM Sleep Is Causal to Successful Consolidation of Dangerous and Safety Stimuli and Reduces Return of Fear after Extinction. Journal of Neuroscience 36, no. 7 (Feb. 2016): 21482160.

213

M. Razzoli, C. Karsten, J. M. Yoder, A. Bartolomucci, and W. C. Engeland, Chronic Subordination Stress Phase Advances Adrenal and Anterior Pituitary Clock Gene Rhythms. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 307, no. 2 (Jul. 2014): R198205.

214

Y. Tahara, T. Shiraishi, Y. Kikuchi, A. Haraguchi, D. Kuriki, H. Sasaki, H. Motohashi, T. Sakai, and S. Shibata, Entrainment of the Mouse Circadian Clock by Sub-acute Physical and Psychological Stress. Scientific Reports 5 (Jun. 2015): 11417.

215

P. D. Mavroudis, S. A. Corbett, S. E. Calvano, and I. P. Androulakis, Mathematical Modeling of Light-mediated HPA Axis Activity and Downstream Implications on the Entrainment of Peripheral Clock Genes. Physiological Genomics 46, no. 20 (Oct. 2014): 766778.

216

P. Pezük, J. A. Mohawk, L. A. Wang, and M. Menaker, Glucocorticoids as Entraining Signals for Peripheral Circadian Oscillators. Endocrinology 153, no. 10 (Oct. 2012): 47754783.

217

P. D. Mavroudis, J. D. Scheff, S. E. Calvano, S. F. Lowry, and I. P. Androulakis, Entrainment of Peripheral Clock Genes by Cortisol. Physiological Genomics 44, no. 11 (2012): 607621.

218

L. D. Grandin, L. B. Alloy, and L. Y. Abramson, The Social Zeitgeber Theory, Circadian Rhythms, and Mood Disorders: Review and Evaluation. Clinical Psychology Review 26, no. 6 (Oct. 2006): 679694.

219

B. Etain, V. Milhiet, F. Bellivier, and M. Leboyer, Genetics of Circadian Rhythms and Mood Spectrum Disorders. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology 21, no. 4 (2011): S676682.

220

P. Pevet and E. Challet, Melatonin: Both Master Clock Output and Internal Time-giver in the Circadian Clocks Network. Journal of Physiology Paris 105, nos. 46 (Dec. 2011): 170182.

221

E. Grossman, M. Laudon, and N. Zisapel, Effect of Melatonin on Nocturnal Blood Pressure: Meta-analysis of Randomized Controlled Trials. Journal of Vascular Health and Risk Management 7 (2011): 577584.

222

F. Simko, T. Baka, L. Paulis, and R. J. Reiter, Elevated Heart Rate and Nondipping Heart Rate as Potential Targets for Melatonin: A Review. Journal of Pineal Research 61, no. 2 (Sept. 2016): 127137.

223

M. D. Muller, C. L. Sauder, and C. A. Ray, Melatonin Attenuates the Skin Sympathetic Nerve Response to Mental Stress. American Journal of Physiology Heart and Circulatory Physiology 305, no. 9 (Nov. 2013): H13821386.

224

N. Ruksee, W. Tongjaroenbuangam, T. Mahanam, and P. Govitrapong, Melatonin Pretreatment Prevented the Effect of Dexamethasone Negative Alterations on Behavior and Hippocampal Neurogenesis in the Mouse Brain. Journal of Steroid Biochemistry and Molecular Biology 143 (Sept. 2014): 7280.

225

F. Boulle, R. Massart, E. Stragier, et al., Hippocampal and Behavioral Dysfunctions in a Mouse Model of Environmental Stress: Normalization by Agomelatine. Translational Psychiatry 4, no. 11 (2014): e485.

226

D. F. Kripke, J. A. Elliott, D. K. Welsh, and S. D. Youngstedt, Photoperiodic and Circadian Bifurcation Theories of Depression and Mania. F1000Research 4 (May 2015): 107.

227

T. E. Henriksen, S. Skrede, O. B. Fasmer, H. Schoeyen, I. Leskauskaite, J. Bjørke-Bertheussen, J. Assmus, B. Hamre, J. Grønli, and Lund, Blue-blocking Glasses as Additive Treatment for Mania: A Randomized Placebo-controlled Trial. Bipolar Disorders 18, no. 3 (May 2016): 221232.

228

A. J. Lewy, The Dim Light Melatonin Onset, Melatonin Assays and Biological Rhythm Research in Humans. Biological Signals and Receptors 8, nos. 12 (Jan. 1999): 7983.

229

A. Wahnschaffe, S. Haedel, A. Rodenbeck, et al., Out of the Lab and into the Bathroom: Evening Short-term Exposure to Conventional Light Suppresses Melatonin and Increases Alertness Perception. International Journal of Molecular Sciences 14, no. 2 (2013): 25732589.

230

T. Kozaki, A. Kubokawa, R. Taketomi, and K. Hatae, Light-induced Melatonin Suppression at Night after Exposure to Different Wavelength Composition of Morning Light. Neuroscience Letters 616 (Jan. 2016): 14.

231

V. Gabel, M. Maire, C. F. Reichert, S. L. Chellappa, C. Schmidt, V. Hommes, A. U. Viola, and C. Cajochen, Effects of Artificial Dawn and Morning Blue Light on Daytime Cognitive Performance, Well-being, Cortisol and Melatonin Levels. Chronobiology International 30, no. 8 (Oct. 2013): 988997.

232

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233

C. A. Czeisler, R. E. Kronauer, J. S. Allan, J. F. Duffy, M. E. Jewett, E. N. Brown, and J. M. Ronda, Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker. Science 244, no. 4910 (Jun. 1989): 13281333.

234

S. J. Kim, S. Benloucif, K. J. Reid, S. Weintraub, N. Kennedy, L. F. Wolfe, and P. C. Zee, Phase-shifting Response to Light in Older Adults. The Journal of Physiology 592, Pt. 1 (2014): 189202.

235

K. Dewan, S. Benloucif, K. Reid, L. F. Wolfe, and P. C. Zee, Lightinduced Changes of the Circadian Clock of Humans: Increasing Duration is More Effective than Increasing Light Intensity. Sleep 34, no. 5 (May 2011): 593599.

236

M. Rüger, M. A. St. Hilaire, G. C. Brainard, S. B. Khalsa, R. E. Kronauer, C. A. Czeisler, et al., Human Phase Response Curve to a Single 6.5 h Pulse of Short-wavelength Light. Journal of Physiology 591 (2013): 353363.

237

K. Wada, S. Yata, O. Akimitsu, M. Krejci, T. Noji, M. Nakade, H. Takeuchi, and T. Harada, A Tryptophan-rich Breakfast and Exposure to Light with Low Color Temperature at Night Improve Sleep and Salivary Melatonin Level in Japanese Students. Journal of Circadian Rhythms 11 (May 2013): 4.

238

H. Fukushige, Y. Fukuda, M. Tanaka, K. Inami, K. Wada, Y. Tsumura, M. Kondo, T. Harada, T. Wakamura, and T. Morita, Effects of Tryptophan-rich Breakfast and Light Exposure during the Daytime on Melatonin Secretion at Night. Journal of Physiological Anthropology 33 (Nov. 2014): 33.

239

Y. Aguilera, M. Rebollo-Hernanz, T. Herrera, L. T. Cayuelas, P. Rodríguez-Rodríguez, Á. L. de Pablo, S. M. Arribas, and M. A. Martin-Cabrejas, Intake of Bean Sprouts Influences Melatonin and Antioxidant Capacity Biomarker Levels in Rats. Food & Function 7, no. 3 (Mar. 2016): 14381445.

240

G. Howatson, P. G. Bell, J. Tallent, B. Middleton, M. P. McHugh, and J. Ellis, Effect of Tart Cherry Juice (Prunus cerasus) on Melatonin Levels and Enhanced Sleep Quality. European Journal of Nutrition (2012): 909916.

241

.

242

A. Asher, A. Shabtay, A. Brosh, H. Eitam, R. Agmon, M. CohenZinder, A. E. Zubidat, and A. Haim, Chrono-functional Milk: The Difference between Melatonin Concentrations in Night-milk versus Day-milk under Different Night Illumination Conditions. Chronobiology International 32, no. 10 (2015): 14091416.

243

R. H. Goo, J. G. Moore, E. Greenberg, et al., Circadian Variation in Gastric Emptying of Meals in Humans. Gastroenterology 93 (1987): 515518.

244

S. S. Rao, P. Sadeghi, J. Beaty, et al., Ambulatory 24-h Colonic Manometry in Healthy Humans. American Journal of Physiology: Gastrointestinal and Liver Physiology 280 (2001): G629G639.

245

S. S. Han, R. Zhang, R. Jain, et al., Circadian Control of Bile Acid Synthesis by a Klf15-fgf15 Axis. Nature Communications 6 (2015): 7231.

246

A. Zarrinpar, A. Chaix, S. Yooseph, et al., Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome. Cell Metabolism 20 (2014): 10061017.

247

J. Lund, J. Arendt, S. M. Hampton, J. English, and L. M. Morgan, Postprandial Hormone and Metabolic Responses amongst Shift Workers in Antarctica. Journal of Endocrinology 171, no. 3 (Dec. 2001): 557564.

248

P. Rubio-Sastre, F. A. Scheer, P. Gómez-Abellán, J. A. Madrid, and M. Garaulet, Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep 37, no. 10 (Oct. 2014): 17151719.

249

C. Vollmers, S. Gill, L. DiTacchio, S. R. Pulivarthy, H. D. Le, and S. Panda, Time of Feeding and the Intrinsic Circadian Clock Drive Rhythms in Hepatic Gene Expression. Proceedings of the National Academy of Sciences of the United States of America 106, no. 50 (Dec. 2009): 2145321458.

250

A. Hirao, H. Nagahama, T. Tsuboi, M. Hirao, Y. Tahara, and S. Shibata, Combination of Starvation Interval and Food Volume Determines the Phase of Liver Circadian Rhythm in Per2: Luc Knock-in Mice under Two Meals per Day Feeding. American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 5 (2010): G10451053.

251

H. Kuroda, Y. Tahara, K. Saito, N. Ohnishi, Y. Kubo, Y. Seo, et al., Meal Frequency Patterns Determine the Phase of Mouse Peripheral Circadian Clocks. Scientific Reports 2 (2012): 711.

252

R. Hara, K. Wan, H. Wakamatsu, R. Aida, T. Moriya, M. Akiyama, et al., Restricted Feeding Entrains Liver Clock without Participation of the Suprachiasmatic Nucleus. Genes to Cells 6, no. 3 (2001): 269278.

253

T. Yoshizaki, Y. Tada, A. Hida, A. Sunami, Y. Yokoyama, J. Yasuda, Nakai, F. Togo, and Y. Kawano, Effects of Feeding Schedule Changes on the Circadian Phase of the Cardiac Autonomic Nervous System and Serum Lipid Levels. European Journal of Applied Physiology 113, no. 10 (Oct. 2013): 26032611.

254

C. Bandín, F. A. Scheer, A. J. Luque, V. Avila-Gandía, S. Zamora, J. A. Madrid, P. Gómez-Abellán, and M. Garaulet, Meal Timing Affects Glucose Tolerance, Substrate Oxidation and Circadianrelated Variables: A Randomized, Crossover Trial. International Journal of Obesity 39, no. 5 (May 2015): 828833.

255

M. Hatori, C. Vollmers, A. Zarrinpar, L. DiTacchio, E. A. Bushong, S. Gill, M. Leblanc, A. Chaix, M. Joens, J. A. Fitzpatrick, M. H. Ellisman, and S. Panda, Time-restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-fat Diet. Cell Metabolism 15, no. 6 (Jun. 2012): 848860.

256

D. Jakubowicz, M. Barnea, J. Wainstein, et al., High Caloric Intake at Breakfast vs. Dinner Differentially Influences Weight Loss of Overweight and Obese Women. Obesity 21 (2013): 25042512.

257

Y. Yamanaka, S. Hashimoto, N. N. Takasu, Y. Tanahashi, S. Y. Nishide, S. Honma, and K. Honma, Morning and Evening Physical Exercise Differentially Regulate the Autonomic Nervous System during Nocturnal Sleepin Humans. American Journalof Physiology Regulatory, Integrative and Comparative Physiology 309, no. 9 (Nov. 2015): R11121121.

258

M. R. Ebben and A. J. Spielman, The Effects of Distal Limb Warming on Sleep Latency. International Journal of Behavioral Medicine 13, no. 3 (2006): 221228.

259

T. M. Burke, R. R. Markwald, A. W. McHill, E. D. Chinoy, J. A. Snider, S. C. Bessman, C. M. Jung, J. S. ONeill, and K. P. Wright Jr., Effects of Caffeine on the Human Circadian Clock in vivo and in vitro. Science Translational Medicine 7, no. 305 (Sept. 2015): 305ra146.

260

http://www.mayoclinic.org/healthylifestyle/nutritionand-healthy-eating/in-depth/caffeine/art-20045678.

261

H. Slama, G. Deliens, R. Schmitz, P. Peigneux, and R. Leproult, Afternoon Nap and Bright Light Exposure Improve Cognitive Flexibility Post Lunch. PLoS ONE10, no. 5 (May 2015): e0125359.

262

H. Baek and B. K. Min, Blue Light Aids in Coping with the Postlunch Dip: An EEG Study. Ergonomics 58, no. 5 (2015): 803810.

263

M. Takahashi and H. Arito, Maintenance of Alertness and Performance by a Brief Nap after Lunch under Prior Sleep Deficit. Sleep 23, no. 6 (Sept. 2000): 813819.

264

M. Takahashi, H. Fukuda, and H. Arito, Brief Naps during Postlunch Rest: Effects on Alertness, Performance, and Autonomic Balance. European Journal of Applied Physiology and Occupational Physiology 78, no. 2 (Jul. 1998): 9398.

265

J. A. Groeger, J. C. Lo, C. G. Burns, and D. J. Dijk, Effects of Sleep Inertia after Daytime Naps Vary with Executive Load and Time of Day. Behavioral Neuroscience 125, no. 2 (Apr. 2011): 252260.

266

M. Tamaki, A. Shirota, M. Hayashi, and T. Hori, Restorative Effects of a Short Afternoon Nap (<30 min) in the Elderly on Subjective Mood, Performance and EEG Activity. Sleep Research Online 3 (2000): 131139.

267

K. Müller, L. Libuda, A. M. Terschlüsen, and M. Kersting, A Review of the Effects of Lunch on Adults Short-term Cognitive Functioning. Canadian Journal of Dietetic Practice and Research 74, no. 4 (2013): 181188.

268

L. A. Reyner, S. J. Wells, V. Mortlock, and J. A. Horne, Post-lunch Sleepiness during Prolonged, Monotonous Driving Effects of Meal Size. Physiology & Behavior 105, no. 4 (Feb. 2012): 10881091.

269

L. V. Borovikova, S. Ivanova, M. Zhang, H. Yang, G. I. Botchkina, L. R. Watkins, H. Wang, N. Abumrad, J. W. Eaton, and K. J. Tracey, Vagus Nerve Stimulation Attenuates the Systemic Inflammatory Response to Endotoxin. Nature 405 (2000): 458462.

270

L. V. Borovikova, S. Ivanova, M. Zhang, H. Yang, G. I. Botchkina, L. R. Watkins, H. Wang, N. Abumrad, J. W. Eaton, and K. J. Tracey, Vagus Nerve Stimulation Attenuates the Systemic Inflammatory Response to Endotoxin. Nature 405 (2000): 458462.

271

J. A. Sturgeon, A. Arewasikporn, M. A. Okun, M. C. Davis, A. D. Ong, and A. J. Zautra, The Psychosocial Context of Financial Stress: Implications for Inflammation and Psychological Health. Psychosomatic Medicine 78, no. 2 (Nov. 2015): 134143.

272

G. E. Miller, E. Chen, J. Sze, T. Marin, J. M. Arevalo, R. Doll, et al., A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-kappaB Signaling. Biological Psychiatry 64 (2008): 266272.

273

Z. Visnovcova, D. Mokra, P. Mikolka, M. Mestanik, A. Jurko, M. Javorka, A. Calkovska, and I. Tonhajzerova, Alterations in Vagalimmune Pathway in Long-lasting Mental Stress. Advances in Experimental Medicine and Biology 832 (2015): 4550.

274

H. Besedovsky, A. del Rey, E. Sorkin, and C. A. Dinarello, Immunoregulatory Feedback between Interleukin-1 and Glucocorticoid Hormones. Science 233, no. 4764 (Aug. 1986): 652654.

275

When your immune system detects invading viruses and bacteria, it releases inflammatory agents. One such agent is interleukin-1 or IL-1. IL-1 triggers the release of the stress hormone cortisol by setting off a chain of commands along the stress axis.

276

R. Dantzer, J. C. OConnor, G. G. Freund, R. W. Johnson, and K. W. Kelley, From Inflammation to Sickness and Depression: When the Immune System Subjugates the Brain. Nature Reviews Neuroscience 9, no. 1 (Jan. 2008): 4656.

277

P. W. Gold, The Organization of the Stress System and its Dysregulation in Depressive Illness. Molecular Psychiatry 20, no. 1 (Feb. 2015): 3247.

278

T. W. Pace, F. Hu, and A. H. Miller, Cytokine-effects on Glucocorticoid Receptor Function: Relevance to Glucocorticoid Resistance and the Pathophysiology and Treatment of Major Depression. Brain, Behavior, and Immunity 21 (2007): 919.

279

C. L. Raison and A. H. Miller, When Not Enough is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-related Disorders. American Journal of Psychiatry 160 (2003): 15541565.

280

A. Bierhaus, J. Wolf, M. Andrassy, et al., A Mechanism Converting Psychosocial Stress into Mononuclear Cell Activation. Proceedings of the National Academy of Sciences of the United States of America 100, no. 4 (2003): 19201925.

281

M. Iwata, K. T. Ota, X. Y. Li, F. Sakaue, N. Li, S. Dutheil, M. Banasr, V. Duric, T. Yamanashi, K. Kaneko, K. Rasmussen, A. Glasebrook, A. Koester, D. Song, K. A. Jones, S. Zorn, G. Smagin, and R. S. Duman, Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biological Psychiatry 80, no. 1 (Dec. 2015): 1222.

282

Y. Zhang, L. Liu, Y. Z. Liu, X. L. Shen, T. Y. Wu, T. Zhang, W. Wang, Y. X. Wang, and C. L. Jiang, NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation. International Journal of Neuropsychopharmacology 18, no. 8 (Jan. 2015), pii: pyv006.

283

M. Tartter, C. Hammen, J. E. Bower, P. A. Brennan, and S. Cole, Effects of Chronic Interpersonal Stress Exposure on Depressive Symptoms Are Moderated by Genetic Variation at IL6 and IL1β in Youth. Brain, Behavior, and Immunity 46 (May 2015): 104111.

284

M. Ozawa, M. Shipley, M. Kivimaki, A. Singh-Manoux, and E. J. Brunner, Dietary Pattern, Inflammation and Cognitive Decline: The Whitehall II Prospective Cohort Study. Clinical Nutrition (Jan. 2016): pii: S02615614(16)000352.

285

C. L. Raison, L. Capuron, and A. H. Miller, Cytokines Sing the Blues: Inflammation and the Pathogenesis of Depression. Trends in Immunology 27 (2006): 2431.

286

C. L. Raison, R. E. Rutherford, B. J. Woolwine, et al., A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-resistant Depression: The Role of Baseline Inflammatory Biomarkers. JAMA Psychiatry 70 (2013): 3141.

287

P. Yang, Z. Gao, H. Zhang, Z. Fang, C. Wu, H. Xu, and Q. J. Huang, Changes in Proinflammatory Cytokines and White Matter in Chronically Stressed Rats. Neuropsychiatric Disease and Treatment 11 (Mar. 2015): 597607.

288

B. Leonard and M. Maes, Mechanistic Explanations How Cellmediated Immune Activation, Inflammation, and Oxidative and Nitrosative Stress Pathways and Their Sequels and Concomitants Play a Role in the Pathophysiology of Unipolar Depression. Neuroscience & Biobehavioral Reviews 36 (2012): 764785.

289

I. Goshen, T. Kreisel, O. Ben-Menachem-Zidon, T. Licht, J. Weidenfeld, T. Ben-Hur, et al., Brain Interleukin-1 Mediates Chronic Stress-induced Depression in Mice via Adrenocortical Activation and Hippocampal Neurogenesis Suppression. Molecular Psychiatry 13 (2008): 717728.

290

J. L. Jankowsky and P. H. Patterson, Cytokine and Growth Factor Involvement in Long-term Potentiation. Molecular and Cellular Neuroscience 14, nos. 45 (Oct. Nov. 1999): 273286.

291

G. Ravaglia, P. Forti, F. Maioli, N. Brunetti, M. Martelli, L. Servadei, L. Bastagli, M. Bianchin, and E. Mariani, Serum C-reactive Protein and Cognitive Function in Healthy Elderly Italian Community Dwellers. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60, no. 8 (Aug. 2005): 10171021.

292

J. N. Trollor, E. Smith, E. Agars, S. A. Kuan, B. T. Baune, L. Campbell, et al., The Association between Systemic Inflammation and Cognitive Performance in the Elderly: The Sydney Memory and Ageing Study. Age 34 (2012): 12951308, 10.1007/s113570119301-x.

293

S. M. Heringa, E. van den Berg, Y. D. Reijmer, G. Nijpels, C. D. Stehouwer, C. G. Schalkwijk, T. Teerlink, P. G. Scheffer, K. van den Hurk, L. J. Kappelle, J. M. Dekker, and G. J. Biessels, Markers of Low-grade Inflammation and Endothelial Dysfunction Are Related to Reduced Information Processing Speed and Executive Functioning in an Older Population the Hoorn Study. Psychoneuroendocrinology 40 (Feb. 2014): 108118.

294

A. J. Ocon, Caught in the Thickness of Brain Fog: Exploring the Cognitive Symptoms of Chronic Fatigue Syndrome. Frontiers in Physiology 4 (Apr. 2013): 63.

295

G. Lange, J. Steffener, D. B. Cook, B. M. Bly, C. Christodoulou, W. C. Liu, J. Deluca, and B. H. Natelson, Objective Evidence of Cognitive Complaints in Chronic Fatigue Syndrome: A BOLD fMRI Study of Verbal Working Memory. Neuroimage 26, no. 2 (Jun. 2005): 513524.

296

D. B. Cook, P. J. OConnor, G. Lange, and J. Steffener, Functional Neuroimaging Correlates of Mental Fatigue Induced by Cognition among Chronic Fatigue Syndrome Patients and Controls. Neuroimage 36, no. 1 (May 2007): 108122.

297

G. Morris, M. Berk, K. Walder, and M. Maes, Central Pathways Causing Fatigue in Neuro-inflammatory and Autoimmune Illnesses. BMC Medicine 13 (2015): 28, doi: 10.1186/s12916-014-0259-2.

298

T. C. Theoharides, J. M. Stewart, S. Panagiotidou, and I. Melamed, Mast Cells, Brain Inflammation and Autism. European Journal of Pharmacology (May 2015): pii: S00142999(15)003982.

299

T. W. Costantini, V. Bansal, C. Y. Peterson, et al., Efferent Vagal Nerve Stimulation Attenuates Gut Barrier Injury after Burn: Modulation of Intestinal Occludin Expression. Journal of Trauma 68, no. 6 (2010): 13491356.

300

J. S. Grigoleit, J. S. Kullmann, O. T. Wolf, F. Hammes, A. Wegner, S. Jablonowski, H. Engler, E. Gizewski, R. Oberbeck, and M. Schedlowski, Dose-dependent Effects of Endotoxin on Neurobehavioral Functions in Humans. PLoS ONE6 (2011): e28330.

301

J. S. Kullmann, J. S. Grigoleit, P. Lichte, P. Kobbe, C. Rosenberger, C. Banner, O. T. Wolf, H. Engler, R. Oberbeck, S. Elsenbruch, U. Bingel, M. Forsting, E. R. Gizewski, and M. Schedlowski, Neural Response to Emotional Stimuli during Experimental Human Endotoxemia. Human Brain Mapping 34, no. 9 (Sept. 2013): 22172227.

302

L. Giloteaux, J. K. Goodrich, W. A. Walters, S. M. Levine, R. E. Ley, and M. R. Hanson, Reduced Diversity and Altered Composition of the Gut Microbiome in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Microbiome 4 (2016): 30.

303

T. Vanuytsel, S. van Wanrooy, H. Vanheel, C. Vanormelingen, S. Verschueren, E. Houben, S. Salim Rasoel, J. Tόth, L. Holvoet, R. Farré, L. van Oudenhove, G. Boeckxstaens, K. Verbeke, and J. Tack, Psychological Stress and Corticotropin-releasing Hormone Increase Intestinal Permeability in Humans by a Mast Cell-dependent Mechanism. Gut 63, no. 8 (Aug. 2014): 12931299.

304

M. Krzyzaniak, C. Peterson, W. Loomis, et al., Postinjury Vagal Nerve Stimulation Protects against Intestinal Epithelial Barrier Breakdown. Journal of Trauma 70, no. 5 (2011): 11681176, doi: 10.1097/TA.0b013e318216f754.

305

J. M. Van Houten, R. J. Wessells, H. L. Lujan, and S. E. DiCarlo, My Gut Feeling Says Rest: Increased Intestinal Permeability Contributes to Chronic Diseases in High-intensity Exercisers. Medical Hypotheses 85, no. 6 (Dec. 2015): 882886.

306

X. Li, E. M. Kan, J. Lu, Y. Cao, R. K. Wong, A. Keshavarzian, and C. H. Wilder-Smith, Combat-training Increases Intestinal Permeability, Immune Activation and Gastrointestinal Symptoms in Soldiers. Alimentary Pharmacology and Therapeutics 37, no. 8 (Apr. 2013): 799809.

307

P. Schnohr, J. H. OKeefe, J. L. Marott, P. Lange, and G. B. Jensen, Dose of Jogging and Long-term Mortality. Journal of the American College of Cardiology 65 (2015): 411419.

308

S. Alfonso-Loeches, J. Ureña-Peralta, M. J. Morillo-Bargues, U. Gómez-Pinedo, and C. Guerri, Ethanol-induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration across the BBB. Neurochemical Research 41, nos. 12 (Feb. 2016): 193209.

309

V. Purohit, J. C. Bode, C. Bode, D. A. Brenner, M. A. Choudhry, F. Hamilton, Y. J. Kang, A. Keshavarzian, R. Rao, R. B. Sartor, C. Swanson, and J. R. Turner, Alcohol, Intestinal Bacterial Growth, Intestinal Permeability to Endotoxin, and Medical Consequences: Summary of a Symposium. Alcohol 42, no. 5 (Aug. 2008): 349361.

310

A. Keshavarzian, S. Choudhary, E. W. Holmes, S. Yong, A. Banan, S. Jakate, and J. Z. Fields, Preventing Gut Leakiness by Oats Supplementation Ameliorates Alcohol-induced Liver Damage in Rats. Journal of Pharmacology and Experimental Therapeutics 299, no. 2 (Nov. 2001): 442448.

311

A. Mackie, N. Rigby, P. Harvey, and B. Bajka, Increasing Dietary Oat Fibre Decreases the Permeability of Intestinal Mucus. Journal of Functional Foods 26 (Oct. 2016): 418427.

312

G. R. Swanson, A. Gorenz, M. Shaikh, V. Desai, C. Forsyth, L. Fogg, H. J. Burgess, and A. Keshavarzian, Decreased Melatonin Secretion is Associated with Increased Intestinal Permeability and Marker of Endotoxemia in Alcoholics. American Journal of Physiology: Gastrointestinal and Liver Physiology 308, no. 12 (Jun. 2015): G10041011.

313

, ( . resistere ), , ; .

314

S. Toden, A. R. Bird, D. L. Topping, and M. A. Conlon, Resistant Starch Prevents Colonic DNA Damage Induced by High Dietary Cooked Red Meat or Casein in Rats. Cancer Biology & Therapy 5, no. 3 (Mar. 2006): 267272.

315

S. Sonia, F. Witjaksono, and R. Ridwan, Effect of Cooling of Cooked White Rice on Resistant Starch Content and Glycemic Response. Asia Pacific Journal of Clinical Nutrition 24, no. 4 (2015): 620625.

316

Y. Murakami, S. Tanabe, and T. Suzuki, High-fat Diet-induced Intestinal Hyperpermeability is Associated with Increased Bile Acids in the Large Intestine of Mice. Journal of Food Science 81, no. 1 (Jan. 2016): H216222.

317

F. Bianchini, G. Caderni, P. Dolara, L. Fantetti, and D. Kriebel, Effect of Dietary Fat, Starch and Cellulose on Fecal Bile Acids in Mice. Journal of Nutrition 119, no. 11 (Nov. 1989): 16171624.

318

B. Benoit, P. Plaisancié, A. Géloën, M. Estienne, C. Debard, E. Meugnier, E. Loizon, P. Daira, J. Bodennec, O. Cousin, H. Vidal, F. Laugerette, and M. C. Michalski, Pasture v. Standard Dairy Cream in High-Fat Diet-Fed Mice: Improved Metabolic Outcomes and Stronger Intestinal Barrier. British Journal of Nutrition 112, no. 4 (Aug. 2014): 520535.

319

J. Suez, T. Korem, D. Zeevi, G. Zilberman-Schapira, C. A. Thaiss, O. Maza, D. Israeli, N. Zmora, S. Gilad, A. Weinberger, Y. Kuperman, Harmelin, I. Kolodkin-Gal, H. Shapiro, Z. Halpern, E. Segal, and E. Elinav, Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota. Nature 514, no. 7521 (Oct. 2014): 181186.

320

A. Lerner and T. Matthias, Changes in Intestinal Tight Junction Permeability Associated with Industrial Food Additives Explain the Rising Incidence of Autoimmune Disease. Autoimmunity Reviews 14, no. 6 (Jun. 2015): 479489.

321

B. Chassaing, O. Koren, J. K. Goodrich, A. C. Poole, S. Srinivasan, R. E. Ley, and A. T. Gewirtz, Dietary Emulsifiers Impact the Mouse Gut Microbiota Promoting Colitis and Metabolic Syndrome. Nature 519, no. 7541 (Mar. 2015): 9296.

322

N. A. Bokulich and M. J. Blaser, A Bitter Aftertaste: Unintended Effects of Artificial Sweeteners on the Gut Microbiome. Cell Metabolism 20, no. 5 (Nov. 2014): 701703.

323

B. Chassaing, O. Koren, J. K. Goodrich, A. C. Poole, S. Srinivasan, R. E. Ley, and A. T. Gewirtz, Dietary Emulsifiers Impact the Mouse Gut Microbiota Promoting Colitis and Metabolic Syndrome. Nature 519, no. 7541 (Mar. 2015): 9296.

324

K. Yoshikawa, C. Kurihara, H. Furuhashi, T. Takajo, K. Maruta, Y. Yasutake, H. Sato, K. Narimatsu, Y. Okada, M. Higashiyama, C. Watanabe, S. Komoto, K. Tomita, S. Nagao, S. Miura, H. Tajiri, and R. Hokari, Psychological Stress Exacerbates NSAID-induced Small Bowel Injury by Inducing Changes in Intestinal Microbiota and Permeability via Glucocorticoid Receptor Signaling. Journal of Gastroenterology 52, no. 1 (Apr. 2016): 6171.

325

Mackie et al., Increasing Dietary Oat Fibre Decreases the Permeability of Intestinal Mucus. 418427.

326

A. R. Mackie, A. Macierzanka, K. Aarak, N. M. Rigby, R. Parker, G. A. Channell, S. E. Harding, and B. H. Bajka, Sodium Alginate Decreases the Permeability of Intestinal Mucus. Food Hydrocolloids 52 (Jan. 2016): 749755.

327

B. Wang, G. Wu, Z. Zhou, Z. Dai, Y. Sun, Y. Ji, W. Li, W. Wang, C. Liu, F. Han, and Z. Wu, Glutamine and Intestinal Barrier Function. Amino Acids 47, no. 10 (Oct. 2015): 21432154.

328

C. M. Lenders, S. Liu, D. W. Wilmore, L. Sampson, L. W. Dougherty, D. Spiegelman, and W. C. Willett, Evaluation of a Novel Food Composition Database That Includes Glutamine and Other Amino Acids Derived from Gene Sequencing Data. European Journal of Clinical Nutrition 63, no. 12 (Dec. 2009): 14331439.

329

G. C. Sturniolo, V. Di Leo, A. Ferronato, A. DOdorico, and R. DInca, Zinc Supplementation Tightens Leaky Gut in Crohns Disease. Inflammatory Bowel Diseases 7, no. 2 (2001): 9498.

330

G. C. Sturniolo, W. Fries, E. Mazzon, V. Di Leo, M. Barollo, and R. DInca, Effect of Zinc Supplementation on Intestinal Permeability in Experimental Colitis. Journal of Laboratory and Clinical Medicine 139, no. 5 (2002): 311315.

331

E. V. Boll, L. M. Ekström, C. M. Courtin, J. A. Delcour, A. C. Nilsson, I. M. Björck, and E. M. Östman, Effects of Wheat Bran Extract Rich in Arabinoxylan Oligosaccharides and Resistant Starch on Overnight Glucose Tolerance and Markers of Gut Fermentation in Healthy Young Adults. European Journal of Nutrition 55, no. 4 (Jul. 2015): 16611670.

332

J. A. Cho and E. Park, Curcumin Utilizes the Anti-inflammatory Response Pathway to Protect the Intestine against Bacterial Invasion. Nutrition Research and Practice 9, no. 2 (Apr. 2015): 117122.

333

L. Vecchi Brumatti, A. Marcuzzi, P. M. Tricarico, V. Zanin, M. Girardelli, and A. M. Bianco, Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments. Molecules 19, no. 12 (Dec. 2014): 2112721153.

334

A. Assa, L. Vong, L. J. Pinnell, N. Avitzur, K. C. Johnson-Henry, and P. M. Sherman, Vitamin D Deficiency Promotes Epithelial Barrier Dysfunction and Intestinal Inflammation. Journal of Infectious Diseases 210, no. 8 (Oct. 2014): 12961305.

335

T. Raftery, A. R. Martineau, C. L. Greiller, S. Ghosh, D. McNamara, K. Bennett, J. Meddings, and M. OSullivan, Effects of Vitamin D Supplementation on Intestinal Permeability, Cathelicidin and Disease Markers in Crohns Disease: Results from a Randomized Doubleblind Placebo-controlled Study. United European Gastroenterology Journal 3, no. 3 (Jun. 2015): 294302.

336

M. Bashir, B. Prietl, M. Tauschmann, et al., Effects of High Doses of Vitamin D3 on Mucosa-associated Gut Microbiome Vary between Regions of the Human Gastrointestinal Tract. European Journal of Nutrition 55 (2016): 14791489.

337

A. Reyes, M. Haynes, N. Hanson, F. E. Angly, A. C. Heath, F. Rohwer, and J. I. Gordon, Viruses in the Faecal Microbiota of Monozygotic Twins and their Mothers. Nature 466, no. 7304 (Jul. 2010): 334338.

338

http://www.nature.com/news/2010/100714/full/news.2010.353.html. Retrieved Jul. 15, 2016.

339

L. A. David, C. F. Maurice, R. N. Carmody, et al., Diet Rapidly and Reproducibly Alters the Human Gut Microbiome. Nature 505 (2014): 559563.

340

X. Yang, E. Twitchell, G. Li, K. Wen, M. Weiss, J. Kocher, S. Lei, Ramesh, E. P. Ryan, and L. Yuan, High Protective Efficacy of Rice Bran against Human Rotavirus Diarrhea via Enhancing Probiotic Growth, Gut Barrier Function, and Innate Immunity. Scientific Reports 5 (Oct. 2015): 15004.

341

I. Martínez, J. M. Lattimer, K. L. Hubach, J. A. Case, J. Yang, C. G. Weber, J. A. Louk, D. J. Rose, G. Kyureghian, D. A. Peterson, M. D. Haub, and J. Walter, Gut Microbiome Composition is Linked to Whole Grain-induced Immunological Improvements. ISME Journal 7, no. 2 (Feb. 2013): 269280.

342

A. Basson, A. Trotter, A. Rodriguez-Palacios, and F. Cominelli, Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Frontiers in Immunology 7 (Aug. 2016): 290.

343

G. Winther, B. M. Pyndt Jørgensen, B. Elfving, D. S. Nielsen, P. Kihl, S. Lund, D. B. Sørensen, and G. Wegener, Dietary Magnesium Deficiency Alters Gut Microbiota and Leads to Depressive-like Behaviour. Acta Neuropsychiatrica 27, no. 3 (Feb. 2015): 19.

344

K. A. Whalen, M. L. McCullough, W. D. Flanders, T. J. Hartman, S. Judd, and R. M. Bostick, Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults. Journal of Nutrition 146, no. 6 (Jun. 2016): 12171226.

345

, . , , , (60 %), (30 %), (10 %).

346

(, , -) , .

347

C. Rendeiro, D. Vauzour, R. J. Kean, L. T. Butler, M. Rattray, J. P. Spencer, and C. M. Williams, Blueberry Supplementation Induces Spatial Memory Improvements and Region-specific Regulation of Hippocampal BDNF mRNA Expression in Young Rats. Psychopharmacology 223, no. 3 (Oct. 2012): 319330.

348

R. Krikorian, M. D. Shidler, T. A. Nash, W. Kalt, M. R. Vinqvist-Tymchuk, B. Shukitt-Hale, and J. A. Joseph, Blueberry Supplementation Improves Memory in Older Adults. Journal of Agricultural and Food Chemistry 58 (2010): 39964000.

349

E. E. Devore, J. H. Kang, M. M. Breteler, and F. Grodstein, Dietary Intakes of Berries and Flavonoids in Relation to Cognitive Decline. Annals of Neurology 72, no. 1 (Jul. 2012): 135143.

350

https://www.sciencedaily.com/releases/2016/03/160314084821.htm.

351

D. Kelly, R. F. Coen, K. O. Akuffo, S. Beatty, J. Dennison, R. Moran, J. Stack, A. N. Howard, R. Mulcahy, and J. M. Nolan, Cognitive Function and Its Relationship with Macular Pigment Optical Density and Serum Concentrations of its Constituent Carotenoids. Journal of Alzheimers Disease 48, no. 1 (2015): 261277.

352

Y. Ozawa, N. Nagai, M. Suzuki, T. Kurihara, H. Shinoda, M. Watanabe, and K. Tsubota, Effects of Constant Intake of Lutein-rich Spinach on Macular Pigment Optical Density: A Pilot Study. Nippon Ganka Gakkai Zasshi 120, no. 1 (Jan. 2016): 4148.

353

M. Govender, Y. E. Choonara, S. van Vuuren, P. Kumar, L. C. du Toit, and V. Pillay, Design and Evaluation of an Oral Multiparticulate System for Dual Delivery of Amoxicillin and Lactobacillus acidophilus. Future Microbiology 11 (Sept. 2016): 11331145.

354

J. D. Galley and M. T. Bailey, Impact of Stressor Exposure on the Interplay between Commensal Microbiota and Host Inflammation. Gut Microbes 5 (2014): 390396.

355

M. T. Bailey and C. L. Coe, Maternal Separation Disrupts the Integrity of the Intestinal Microflora in Infant Rhesus Monkeys. Developmental Psychobiology 35 (1999): 146155.

356

M. Tanida and K. Nagai, Electrophysiological Analysis of the Mechanism of Autonomic Action by Lactobacilli. Bioscience and Microflora 30, no. 4 (2011): 99109.

357

M. Nishimura, T. Ohkawara, K. Tetsuka, et al., Effects of Yogurt Containing Lactobacillus plantarum HOKKAIDO on Immune Function and Stress Markers. Journal of Traditional and Complementary Medicine 6, no. 3 (2016): 275280.

358

A. V. Rao, A. C. Bested, T. M. Beaulne, M. A. Katzman, C. Iorio, J. M. Berardi, and A. C. Logan, A Randomized, Double-blind, Placebocontrolled Pilot Study of a Probiotic in Emotional Symptoms of Chronic Fatigue Syndrome. Gut Pathogens 1, no. 1 (Mar. 2009): 6.

359

M. Messaoudi, R. Lalonde, N. Violle, H. Javelot, D. Desor, A. Nejdi, J. F. Bisson, C. Rougeot, M. Pichelin, M. Cazaubiel, and J. M. Cazaubiel, Assessment of Psychotropic-like Properties of a Probiotic Formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in Rats and Human Subjects. British Journal of Nutrition 105 (2011): 755764.

360

S. R. Knowles, E. A. Nelson, and E. A. Palombo, Investigating the Role of Perceived Stress on Bacterial Flora Activity and Salivary Cortisol Secretion: A Possible Mechanism Underlying Susceptibility to Illness. Biological Psychology 77 (2008): 132137.

361

L. Desbonnet, L. Garrett, G. Clarke, B. Kiely, J. F. Cryan, and T. G. Dinan, Effects of the Probiotic Bifidobacterium infantis in the Maternal Separation Model of Depression. Neuroscience 170 (2010): 11791188.

362

D. Benton, C. Williams, and A. Brown, Impact of Consuming a Milk Drink Containing a Probiotic on Mood and Cognition. European Journal of Clinical Nutrition 61, no. 3 (Mar. 2007): 355361.

363

K. Tillisch, J. Labus, L. Kilpatrick, et al., Consumption of Fermented Milk Product with Probiotic Modulates Brain Activity. Gastroenterology 144, no. 7 (2013): 13941401.

364

J. A. Bravo, P. Forsythe, M. V. Chew, E. Escaravage, H. M. Savignac, T. G. Dinan, et al., Ingestion of Lactobacillus Strain Regulates Emotional Behavior and Central GABA Receptor Expression in a Mouse via the Vagus Nerve. Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 1605016055.

365

P. A. Mackowiak, Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life. Frontiers in Public Health 1 (2013): 52.

366

Z. Xu and R. Knight, Dietary Effects on Human Gut Microbiome Diversity. British Journal of Nutrition 113, suppl. 0 2015): S1S5.

367

M. Mohamadshahi, M. Veissi, F. Haidari, H. Shahbazian, G. A. Kaydani, and F. Mohammadi, Effects of Probiotic Yogurt Consumption on Inflammatory Biomarkers in Patients with Type 2 Diabetes. BioImpacts 4, no. 2 (2014): 8388.

368

http://www.scientificamerican.com/article/gut-second-brain/. Retrieved Jul. 26, 2015.

369

T. T. Haug, A. Mykletun, and A. A. Dahl, Are Anxiety and Depression Related to Gastrointestinal Symptoms in the General Population? Scandinavian Journal of Gastroenterology 37, no. 3 (Mar. 2002): 294298.

370

R. Spiller, Q. Aziz, F. Creed, A. Emmanuel, L. Houghton, P. Hungin, R. Jones, D. Kumar, G. Rubin, N. Trudgill, and P. Whorwell, Guidelines on the Irritable Bowel Syndrome: Mechanisms and Practical Management. Gut 56, no. 12 (Dec. 2007): 17701798.

371

R. M. Lovell and A. C. Ford, Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis. Clinical Gastroenterology and Hepatology 10, no. 7 (Jul. 2012): 712721.

372

M. M. Wouters, S. van Wanrooy, A. Nguyen, J. Dooley, J. Aguilera-Lizarraga, W. van Brabant, J. E. Garcia-Perez, L. van Oudenhove, M. van Ranst, J. Verhaegen, A. Liston, and G. Boeckxstaens, Psychological Comorbidity Increases the Risk for Postinfectious IBS Partly by Enhanced Susceptibility to Develop Infectious Gastroenteritis. Gut 65, no. 8 (Aug. 2016): 12791288, doi: 10.1136/gutjnl-2015-309460.

373

I. O. Olubuyide, F. Olawuyi, and A. A. Fasanmade, A Study of Irritable Bowel Syndrome Diagnosed by Manning Criteria in an African Population. Digestive Diseases and Sciences 40 (1995): 983985.

374

H. J. Jung, M. I. Park, W. Moon, S. J. Park, H. H. Kim, E. J. Noh, G. J. Lee, J. H. Kim, and D. G. Kim, Are Food Constituents Relevant to the Irritable Bowel Syndrome in Young Adults? A Rome III based Prevalence Study of the Korean Medical Students. Journal of Neurogastroenterology and Motility 17 (2011): 294299.

375

L. C. Phua, C. H. Wilder-Smith, Y. M. Tan, T. Gopalakrishnan, R. K. Wong, X. Li, M. E. Kan, J. Lu, A. Keshavarzian, and E. C. Chan, Gastrointestinal Symptoms and Altered Intestinal Permeability Induced by Combat Training Are Associated with Distinct Metabotypic Changes. Journal of Proteome Research 14, no. 11 (Nov. 2015): 47344742.

376

S. Seyedmirzaee, M. M. Hayatbakhsh, B. Ahmadi, N. Baniasadi, M. Bagheri Rafsanjani, A. R. Nikpoor, and M. Mohammadi, Serum Immune Biomarkers in Irritable Bowel Syndrome. Clinics and Research in Hepatology and Gastroenterology 40, no. 5 (Nov. 2016): 631637.

377

Y. T. Lee, L. Y. Hu, C. C. Shen, M. W. Huang, S. J. Tsai, A. C. Yang, C. K. Hu, C. L. Perng, Y. S. Huang, and J. H. Hung, Risk of Psychiatric Disorders following Irritable Bowel Syndrome: A Nationwide Population-Based Cohort Study. PLoS ONE10, no. 7 (Jul. 2015): e0133283.

378

C. Tana, Y. Umesaki, A. Imaoka, T. Handa, M. Kanazawa, and S. Fukudo, Altered Profiles of Intestinal Microbiota and Organic Acids May Be the Origin of Symptoms in Irritable Bowel Syndrome. Neurogastroenterology & Motility 22, no. 5 (May 2010): 512519, e114115.

379

(Fermentable) - (Oligo-), - (Di-), (- (Mono-) ) (And) (Polyol). , .

380

S. L. Eswaran, W. D. Chey, T. Han-Markey, S. Ball, and K. Jackson, A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D. American Journal of Gastroenterology 111, no. 12 (Dec. 2016): 18241832.

381

L. Böhn, S. Störsrud, T. Liljebo, L. Collin, P. Lindfors, H. Törnblom, and M. Simrén, Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial. Gastroenterology 149, no. 6 (Nov. 2015): 13991407, doi: 10.1053/j.gastro.2015.07.054.

382

T. N. Hustoft, T. Hausken, S. O. Ystad, J. Valeur, K. Brokstad, J. G. Hatlebakk, and G. A. Lied, Effects of Varying Dietary Content of Fermentable Short-chain Carbohydrates on Symptoms, Fecal Microenvironment, and Cytokine Profiles in Patients with Irritable Bowel Syndrome. Neurogastroenterology & Motility (Oct. 2016) (epub ahead of print). doi: 10.1111/nmo.12969.

383

D. Lis, K. D. Ahuja, T. Stellingwerff, C. M. Kitic, and J. Fell, Case Study: Utilizing a Low FODMAP Diet to Combat Exercise-induced Gastrointestinal Symptoms. International Journal of Sport Nutrition and Exercise Metabolism 26, no. 5 (Oct. 2016): 481487.

384

D. Lis, K. D. Ahuja, T. Stellingwerff, C. M. Kitic, and J. Fell, Food Avoidance in Athletes: FODMAP Foods on the List. Applied Physiology, Nutrition, and Metabolism 41, no. 9 (Sept. 2016): 10021004.

385

Y. Junker, S. Zeissig, S. J. Kim, et al., Wheat Amylase Trypsin Inhibitors Drive Intestinal Inflammation via Activation of Toll-like Receptor 4. Journal of Experimental Medicine 209 (2012): 23952408.

386

S. Golley, N. Corsini, D. Topping, et al., Motivations for Avoiding Wheat Consumption in Australia: Results from a Population Survey. Public Health Nutrition 18 (2015): 490499.

387

A. Carroccio, P. Mansueto, G. Iacono, et al., Non-celiac Wheat Sensitivity Diagnosed by Double-blind Placebo-controlled Challenge: Exploring a New Clinical Entity. American Journal of Gastroenterology 107 (2012): 18981906.

388

T. Thompson, Wheat Starch, Gliadin, and the Gluten-free Diet. Journal of the American Dietetic Association 101, no. 12 (Dec. 2001): 14561459.

389

U. Volta, M. I. Pinto-Sanchez, E. Boschetti, G. Caio, R. De Giorgio, and E. F. Verdu, Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?. Journal of Neurogastroenterology and Motility 22, no. 4 (Oct. 2016): 547557.

390

A. P. Marum et al., A Low Fermentable Oligo-di-mono Saccharides and Polyols (FODMAP) Diet Reduced Pain and Improved Daily Life in Fibromyalgia Patients. Scandinavian Journal of Pain 13 (Oct. 2016): 166172.

391

R. Nisihara, A. P. Marques, A. Mei, and T. Skare, Celiac Disease and Fibromyalgia: Is There an Association?. Revista Espanola de Enfermedades Digestivas 108, no. 2 (Feb. 2016): 107108.

392

G. L. Austin, C. B. Dalton, Y. Hu, C. B. Morris, J. Hankins, S. R. Weinland, E. C. Westman, W. S. Yancy, Jr., and D. A. Drossman, A Very Low-carbohydrate Diet Improves Symptoms and Quality of Life in Diarrhea-predominant Irritable Bowel Syndrome. Clinical Gastroenterology and Hepatology 7, no. 6 (Jun. 2009): 706708.

393

A. Kumar, N. Kumar, J. C. Vij, S. K. Sarin, and B. S. Anand, Optimum Dosage of Ispaghula Husk in Patients with Irritable Bowel Syndrome: Correlation of Symptom Relief with Whole Gut Transit Time and Stool Weight. Gut 28, no. 2 (Feb. 1987): 150155.

394

K. Lindfors, T. Blomqvist, K. Juuti-Uusitalo, S. Stenman, J. Venäläinen, M. Mäki, and K. Kaukinen, Live Probiotic Bifidobacterium lactis Bacteria Inhibit the Toxic Effects Induced by Wheat Gliadin in Epithelial Cell Culture. Clinical & Experimental Immunology 152, no. 3 (Jun. 2008): 552558.

395

, : , .

396

S. Guandalini, G. Magazzù, A. Chiaro, V. la Balestra, G. Di Nardo, S. Gopalan, A. Sibal, C. Romano, R. B. Canani, P. Lionetti, and M. Setty, VSL#3 Improves Symptoms in Children with Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo-controlled, Double-blind, Crossover Study. Journal of Pediatric Gastroenterology and Nutrition 51, no. 1 (Jul. 2010): 2430.

397

N. Shivappa, S. E. Steck, T. G. Hurley, J. R. Hussey, and J. R. Hébert, Designing and Developing a Literature-derived, Population-based Dietary Inflammatory Index. Public Health Nutrition 17, no. 8 (Aug. 2014): 16891696.

398

N. Shivappa, S. E. Steck, T. G. Hurley, J. R. Hussey, Y. Ma, I. S. Ockene, F. Tabung, and J. R. Hébert, A Population-based Dietary Inflammatory Index Predicts Levels of C-reactive Protein in the Seasonal Variation of Blood Cholesterol Study. Public Health Nutrition 17, no. 8 (Aug. 2014): 18251833.

399

M. Hafizi Abu Bakar, C. Kian Kai, W. N. Wan Hassan, M. R. Sarmidi, H. Yaakob, and H. Zaman Huri, Mitochondrial Dysfunction as a Central Event for Mechanisms Underlying Insulin Resistance: The Roles of Long Chain Fatty Acids. Diabetes/Metabolism Research and Reviews 31, no. 5 (Jul. 2015): 453475.

400

A. Mancini, E. Imperlini, E. Nigro, C. Montagnese, A. Daniele, S. Orrù, and P. Buono, Biological and Nutritional Properties of Palm Oil and Palmitic Acid: Effects on Health. Molecules 20, no. 9 (Sept. 2015): 1733917361.

401

R. G. Snodgrass, S. Huang, D. Namgaladze, O. Jandali, T. Shao, S. Sama, B. Brüne, and D. H. Hwang, Docosahexaenoic Acid and Palmitic Acid Reciprocally Modulate Monocyte Activation in Part through Endoplasmic Reticulum Stress. Journal of Nutritional Biochemistry 32 (Jun. 2016): 3945.

402

M. Hafizi et al., Mitochondrial Dysfunction as a Central Event for Mechanisms Underlying Insulin Resistance: The Roles of Long Chain Fatty Acids: 453475.

403

S. Montserrat-de la Paz, M. C. Naranjo, B. Bermudez, S. Lopez, W. Moreda, R. Abia, and F. J. Muriana, Postprandial Dietary Fatty Acids Exert Divergent Inflammatory Responses in Retinal-pigmented Epithelium Cells. Food & Function 7, no. 3 (Mar. 2016): 13451353.

404

() .

405

L. M. Varela, B. Bermúdez, A. Ortega-Gómez, S. López, R. Sánchez, J. Villar, C. Anguille, F. J. Muriana, P. Roux, and R. Abia, Postprandial Triglyceride-rich Lipoproteins Promote Invasion of Human Coronary Artery Smooth Muscle Cells in a Fatty-acid Manner through PI3k-Rac1-JNK Signaling. Molecular Nutrition & Food Research 58, no. 6 (Jun. 2014): 13491364.

406

P. D. Cani, R. Bibiloni, C. Knauf, A. Waget, A. M. Neyrinck, N. M. Delzenne, and R. Burcelin, Changes in Gut Microbiota Control Metabolic Endotoxemia-induced Inflammation in High-Fat DietInduced Obesity and Diabetes in Mice. Diabetes 57, no. 6 (Jun. 2008): 14701481.

407

A. L. Kala, V. Joshi, and K. N. Gurudutt, Effect of Heating Oils and Fats in Containers of Different Materials on Their Trans Fatty Acid Content. Journal of the Science of Food and Agriculture 92, no. 11 (Aug. 2012): 22272233.

408

S. Bhardwaj, S. J. Passi, A. Misra, K. K. Pant, K. Anwar, R. M. Pandey, and V. Kardam, Effect of Heating/Reheating of Fats/Oils, as Used by Asian Indians, on Trans Fatty Acid Formation. Food Chemistry 212 (Dec. 2016): 663670.

409

S. H. Ley, Q. Sun, W. C. Willett, et al., Associations between Red Meat Intake and Biomarkers of Inflammation and Glucose Metabolism in Women. American Journal of Clinical Nutrition 99, no. 2 (2014): 352360.

410

F. Alisson-Silva, K. Kawanishi, and A. Varki, Human Risk of Diseases Associated with Red Meat Intake: Analysis of Current Theories and Proposed Role for Metabolic Incorporation of a Non-human Sialic Acid. Molecular Aspects of Medicine 51 (Oct. 2016): 1630.

411

A. N. Samraj, O. M. Pearce, H. Läubli, A. N. Crittenden, A. K. Bergfeld, K. Banda, C. J. Gregg, A. E. Bingman, P. Secrest, S. L. Diaz, N. M. Varki, and A. Varki, A Red Meat-derived Glycan Promotes Inflammation and Cancer Progression. Proceedings of the National Academy of Sciences of the United States of America 112, no. 2 (Jan. 2015): 542547.

412

Samraj et al., A Red Meat-derived Glycan Promotes Inflammation and Cancer Progression. 542547.

413

F. Alisson-Silva, K. Kawanishi, and A. Varki, Human Risk of Diseases Associated with Red Meat Intake: Analysis of Current Theories and Proposed Role for Metabolic Incorporation of a Non-human Sialic Acid. Molecular Aspects of Medicine 51 (Oct. 2016): 1630.

414

B. A. t Hart, Why Does Multiple Sclerosis only Affect Human Primates? Multiple Sclerosis Journal 22, no. 4 (Apr. 2016): 559563.

415

P. Eleftheriou, S. Kynigopoulos, A. Giovou, A. Mazmanidi, J. Yovos, P. Skepastianos, E. Vagdatli, C. Petrou, D. Papara, and M. Efterpiou, Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism. BioMed Research International 2014 (2014): 963230.

416

T. Norat, S. Bingham, P. Ferrari, et al., Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition. Journal of the National Cancer Institute 97 (2005): 906916.

417

L. H. Kushi, C. Doyle, M. McCullough, C. L. Rock, W. DemarkWahnefried, E. V. Bandera, S. Gapstur, A. V. Patel, K. Andrews, and T. Gansler, American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity. CA: A Cancer Journal for Clinicians 62, no. 1 (Jan. Feb. 2012): 3067.

418

R. Sinha, N. Rothman, C. P. Salmon, M. G. Knize, E. D. Brown, C. A. Swanson, D. Rhodes, S. Rossi, J. S. Felton, and O. A. Levander, Heterocyclic Amine Content in Beef Cooked by Different Methods to Varying Degreesof Doneness and Gravy Madefrom Meat Drippings. Food and Chemical Toxicology 36, no. 4 (Apr. 1998): 279287.

419

K. Puangsombat, W. Jirapakkul, and J. S. Smith, Inhibitory Activity of Asian Spices on Heterocyclic Amines Formation in Cooked Beef Patties. Journal of Food Science 76, no. 8 (Oct. 2011): T174180.

420

M. Gibis and J. Weiss, Antioxidant Capacity and Inhibitory Effect of Grape Seed and Rosemary Extract in Marinades on the Formation of Heterocyclic Amines in Fried Beef Patties. Food Chemistry 134, no. 2 (Sept. 2012): 766774.

421

M. Gibis and J. Weiss, Inhibitory Effect of Marinades with Hibiscus Extract on Formation of Heterocyclic Aromatic Amines and Sensory Quality of Fried Beef Patties. Meat Science 85, no. 4 (Aug. 2010): 735742.

422

A. Nuora, V. S. Chiang, A. M. Milan, M. Tarvainen, S. Pundir, S. Y. Quek, G. C. Smith, J. F. Markworth, M. Ahotupa, D. CameronSmith, and K. M. Linderborg, The Impact of Beef Steak Thermal Processing on Lipid Oxidation and Postprandial Inflammation related Responses. Food Chemistry 184 (Oct. 2015): 5764.

423

, , . . .

424

J. de Vogel, D. S. Jonker-Termont, M. B. Katan, and R. van der Meer, Natural Chlorophyll but Not Chlorophyllin Prevents Heme-induced Cytotoxic and Hyperproliferative Effects in Rat Colon. Journal of Nutrition 135, no. 8 (Aug. 2005): 19952000.

425

T. Norat, A. Lukanova, P. Ferrari, and E. Riboli, Meat Consumption and Colorectal Cancer Risk: Dose-response Meta-analysis of Epidemiological Studies. International Journal of Cancer 98 (2002): 241256.

426

J. Uribarri, W. Cai, M. Ramdas, S. Goodman, R. Pyzik, X. Chen, L. Zhu, G. E. Striker, and H. Vlassara, Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes: Potential Role of AGER1 and SIRT1. Diabetes Care 34 (2011): 16101616.

427

M. Negrean, A. Stirban, B. Stratmann, T. Gawlowski, T. Horstmann, C. Gotting, K. Kleesiek, M. Mueller-Roesel, T. Koschinsky, J. Uribarri, H. Vlassara, and D. Tschoepe, Effects of Lowand High-advanced Glycation End Product Meals on Macroand Microvascular Endothelial Function and Oxidative Stress in Patients with Type 2 Diabetes mellitus. American Journal of Clinical Nutrition 85 (2007): 12361243.

428

G. Zhang, G. Huang, L. Xiao, and A. E. Mitchell, Determination of Advanced Glycation End Products by LC MS/MS in Raw and Roasted Almonds (Prunus dulcis). Journal of Agricultural and Food Chemistry 59 (2011): 1203712046.

429

J. Uribarri, S. Woodruff, S. Goodman, W. Cai, X. Chen, R. Pyzik, Yong, G. E. Striker, and H. Vlassara, Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet. Journal of the American Dietetic Association 110 (2010): 911916.

430

L. Pruimboom, C. L. Raison, and F. A. Muskiet, Physical Activity Protects the Human Brain against Metabolic Stress Induced by a Postprandial and Chronic Inflammation. Behavioural Neurology 2015: 569869.

431

M. A. Faris, S. Kacimi, R. A. Al-Kurd, M. A. Fararjeh, Y. K. Bustanji, M. K. Mohammad, and M. L. Salem, Intermittent Fasting during Ramadan Attenuates Proinflammatory Cytokines and Immune Cells in Healthy Subjects. Nutrition Research 32, no. 12 (Dec. 2012): 947955.

432

T. Moro, G. Tinsley, A. Bianco, G. Marcolin, Q. F. Pacelli, G. Battaglia, Palma, P. Gentil, M. Neri, and A. Paoli, Effects of Eight Weeks of Time-restricted Feeding (16/8) on Basal Metabolism, Maximal Strength, Body Composition, Inflammation, and Cardiovascular Risk Factors in Resistance-trained Males. Journal of Translational Medicine 14, no. 1 (Oct. 2016): 290.

433

J. L. Mauriz, P. S. Collado, C. Veneroso, R. J. Reiter, and J. GonzálezGallego, A Review of the Molecular Aspects of Melatonins Antiinflammatory Actions: Recent Insights and New Perspectives. Journal of Pineal Research 54, no. 1 (2013): 114.

434

L. Fontana, Neuroendocrine Factors in the Regulation of Inflammation: Excessive Adiposity and Calorie Restriction. Experimental Gerontology 44 (2009): 4145.

435

S. D. Katewa, K. Akagi, N. Bose, K. Rakshit, T. Camarella, X. Zheng, D. Hall, S. Davis, C. S. Nelson, R. B. Brem, A. Ramanathan, A. Sehgal, J. M. Giebultowicz, and P. Kapahi, Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. Cell Metabolism 23, no. 1 (Jan. 2016): 143154.

436

F. Molica, S. Morel, B. R. Kwak, F. Rohner-Jeanrenaud, and S. Steffens, Adipokines at the Crossroad between Obesity and Cardiovascular Disease. Thrombosis and Haemostasis 113, no. 3 (Mar. 2014): 553566.

437

T. Karrasch and A. Schaeffler, Adipokines and the Role of Visceral Adipose Tissue in Inflammatory Bowel Disease. Annals of Gastroenterology 29, no. 4 (Oct. Dec. 2016): 424438.

438

I. Schlecht, B. Fischer, G. Behrens, and M. F. Leitzmann, Relations of Visceral and Abdominal Subcutaneous Adipose Tissue, Body Mass Index, and Waist Circumference to Serum Concentrations of Parameters of Chronic Inflammation. Obesity Facts 9, no. 3 (2016): 144157.

439

A. Gummesson, L. M. Carlsson, L. H. Storlien, F. Bäckhed, P. Lundin, L. Löfgren, K. Stenlöf, Y. Y. Lam, B. Fagerberg, and B. Carlsson, Intestinal Permeability Is Associated with Visceral Adiposity in Healthy Women. Obesity 19, no. 11 (Nov. 2011): 22802282.

440

G. Escobedo, E. López-Ortiz, and I. Torres-Castro, Gut Microbiota as a Key Player in Triggering Obesity, Systemic Inflammation and Insulin Resistance. Revista de Investigación Clínica 66, no. 5 (Sept. Oct. 2014): 450459.

441

Karrasch et al., Adipokines and the Role of Visceral Adipose Tissue in Inflammatory Bowel Disease. 424438.

442

H. Li, C. Lelliott, P. Håkansson, et al., Intestinal, Adipose, and Liver Inflammation in Diet-induced Obese Mice. Metabolism: Clinical and Experimental 57 (2008): 17041710.

443

M. Kawano, M. Miyoshi, A. Ogawa, F. Sakai, and Y. Kadooka, Lactobacillus gasseri SBT2055 Inhibits Adipose Tissue Inflammation and Intestinal Permeability in Mice Fed a High-fat Diet. Journal of Nutritional Science 5 (2016): e23, doi: 10.1017/jns.2016.12.

444

J. P. Després and I. Lemieux, Abdominal Obesity and Metabolic Syndrome. Nature 444, no. 7121 (Dec. 2006): 881887.

445

.

446

L. E. Gyllenhammer, M. J. Weigensberg, D. Spruijt-Metz, H. Allayee, M. I. Goran, and J. N. Davis, Modifying Influence of Dietary Sugar in the Relationship between Cortisol and Visceral Adipose Tissue in Minority Youth. Obesity 22, no. 2 (2014): 474481.

447

H. R. Hong, J. O. Jeong, J. Y. Kong, S. H. Lee, S. H. Yang, C. D. Ha, and H. S. Kang, Effect of Walking Exercise on Abdominal Fat, Insulin Resistance and Serum Cytokines in Obese Women. Journal of Exercise Nutrition & Biochemistry 18, no. 3 (Sept. 2014): 277285.

448

R. Ross, R. Hudson, P. J. Stotz, and M. Lam, Effects of Exercise Amount and Intensity on Abdominal Obesity and Glucose Tolerance in Obese Adults: A Randomized Trial. Annals of Internal Medicine 162, no. 5 (Mar. 2015): 325334.

449

S. E. Keating, D. A. Hackett, H. M. Parker, H. T. OConnor, J. A. Gerofi, A. Sainsbury, M. K. Baker, V. H. Chuter, I. D. Caterson, J. George, and N. A. Johnson, Effect of Aerobic Exercise Training Dose on Liver Fat and Visceral Adiposity. Journal of Hepatology 63, no. 1 (Jul. 2015): 174182.

450

G. R. Logan, N. Harris, S. Duncan, L. D. Plank, F. Merien, and G. Schofield, Low-active Male Adolescents: A Dose Response to High-intensity Interval Training. Medicine & Science in Sports & Exercise 48, no. 3 (Mar. 2016): 481490.

451

K. E. Koopman, M. W. Caan, A. J. Nederveen, et al., Hypercaloric Diets with Increased Meal Frequency, but not Meal Size, Increase Intrahepatic Triglycerides: A Randomized Controlled Trial. Hepatology 60, no. 2 (2014): 545553.

452

M. Gleeson, N. C. Bishop, D. J. Stensel, et al., The Anti-inflammatory Effects of Exercise: Mechanisms and Implications for the Prevention and Treatment of Disease. Nature Reviews Immunology 11 (2011): 607615.

453

G. I. Lancaster and M. A. Febbraio, The Immunomodulating Role of Exercise in Metabolic Disease. Trends in Immunology (2014): 262269.

454

C. Kasapis and P. D. Thompson, The Effects of Physical Activity on Serum C-reactive Protein and Inflammatory Markers: A Systematic Review. Journal of the American College of Cardiology 45 (2005): 15631569.

455

A. Masuda, M. Nakazato, T. Kihara, S. Minagoe, and C. Tei, Repeated Thermal Therapy Diminishes Appetite Loss and Subjective Complaints in Mildly Depressed Patients. Psychosomatic Medicine 67, no. 4 (Jul. Aug. 2005): 643647.

456

C. W. Janssen, C. A. Lowry, M. R. Mehl, J. J. Allen, K. L. Kelly, D. E. Gartner, A. Medrano, T. K. Begay, K. Rentscher, J. J. White, A. Fridman, L. J. Roberts, M. L. Robbins, K. U. Hanusch, S. P. Cole, and C. L. Raison, Whole-body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry 73, no. 8 (Aug. 2016): 789795.

457

M. Bauer, S. Berman, T. Stamm, M. Plotkin, M. Adli, M. Pilhatsch, E. D. London, G. S. Hellemann, P. C. Whybrow, and F. Schlagenhauf, Levothyroxine Effects on Depressive Symptoms and Limbic Glucose Metabolism in Bipolar Disorder: A Randomized, Placebocontrolled Positron Emission Tomography Study. Molecular Psychiatry 21, no. 2 (Feb. 2016): 229236.

458

M. Krause, M. S. Ludwig, T. G. Heck, and H. K. Takahashi, Heat Shock Proteins and Heat Therapy for Type 2 Diabetes: Pros and Cons. Current Opinion in Clinical Nutrition and Metabolic Care 18, no. 4 (Jul. 2015): 374380.

459

T. Laukkanen, S. Kunutsor, J. Kauhanen, and J. A. Laukkanen, Sauna Bathing is Inversely Associated with Dementia and Alzheimers Disease in Middle-aged Finnish Men. Age and Ageing 1, no. 5 (Dec. 2016) (epub ahead of print) doi: 10.1093/ageing/afw212.

460

P. Cassano, S. R. Petrie, M. R. Hamblin, T. A. Henderson, and D. V. Iosifescu, Review of Transcranial Photobiomodulation for Major Depressive Disorder: Targeting Brain Metabolism, Inflammation, Oxidative Stress, and Neurogenesis. Neurophotonics 3, no. 3 (Jul. 2016): 031404.

461

L. Detaboada et al., Transcranial Application of Low-energy Laser Irradiation Improves Neurological Deficits in Rats Following Acute Stroke. Lasers in Surgery and Medicine 38, no. 1 (2006): 7073.

462

H. Araki et al., Reduction of Interleukin-6 Expression in Human Synoviocytes and Rheumatoid Arthritis Rat Joints by Linear Polarized Near Infrared Light (Superlizer) Irradiation. Laser Therapy 20, no. 4 (2011): 293.

463

M. Yamaura et al., Low Level Light Effects on Inflammatory Cytokine Production by Rheumatoid Arthritis Synoviocytes. Lasers in Surgery and Medicine 41, no. 4 (2009): 282290.

464

J. Khuman et al., Low-level Laser Light Therapy Improves Cognitive Deficits and Inhibits Microglial Activation after Controlled Cortical Impact in Mice. Journal of Neurotrauma 29, no. 2 (2012): 408417.

465

J. C. Rojas, A. K. Bruchey, and F. Gonzalez-Lima, Low-level Light Therapy Improves Cortical Metabolic Capacity and Memory Retention. Journal of Alzheimers Disease 32, no. 3 (2012): 741752.

466

D. Barrett and F. Gonzalez-Lima, Transcranial Infrared Laser Stimulation Produces Beneficial Cognitive and Emotional Effects in Humans. Neuroscience 230 (2013): 1323.

467

.

468

X. Qin and E. A. Deitch, Dissolution of Lipids from Mucus: A Possible Mechanism for Prompt Disruption of Gut Barrier Function by Alcohol. Toxicology Letters 232, no. 2 (Jan. 2015): 356362.

469

J. Connor, Alcohol Consumption as a Cause of Cancer. Addiction 112, no. 2 (Feb. 2017): 222228.

470

R. Nirupama, M. Devaki, and H. N. Yajurvedi, Chronic Stress and Carbohydrate Metabolism: Persistent Changes and Slow Return to Normalcy in Male Albino Rats. Stress 15, no. 3 (May 2012): 262271.

471

S. Garbarino and N. Magnavita, Work Stress and Metabolic Syndrome in Police Officers. A Prospective Study. ed. V. Grolmusz, PLoS ONE10, no. 12 (2015): e0144318.

472

A. Hino, A. Inoue, K. Mafune, T. Nakagawa, T. Hayashi, and H. Hiro, Changes in the Psychosocial Work Characteristics and Insulin Resistance among Japanese Male Workers: A Three-year Follow-up Study. Journal of Occupational Health 58, no. 6 (Nov. 2016): 543562.

473

B. Schmidt, J. A. Bosch, M. N. Jarczok, R. M. Herr, A. Loerbroks, E. van Vianen, and J. E. Fischer, Effort-reward Imbalance Is Associated with the Metabolic Syndrome Findings from the Mannheim Industrial Cohort Study (MICS). International Journal of Cardiology 178 (Jan. 2015): 2428.

474

T. Almadi, I. Cathers, and C. M. Chow, Associations among Workrelated Stress, Cortisol, Inflammation, and Metabolic Syndrome. Psychophysiology 50, no. 9 (Sept. 2013): 821830.

475

V. K. Tsenkova, D. Carr, C. L. Coe, and C. D. Ryff, Anger, Adiposity, and Glucose Control in Nondiabetic Adults: Findings from Midus II. Journal of Behavioral Medicine 37, no. 1 (2014): 3746.

476

K. Räikkönen, L. Keltikangas-Järvinen, and A. Hautanen, The Role of Psychological Coronary Risk Factors in Insulin and Glucose Metabolism. Journal of Psychosomatic Research 38, no. 7 (Oct. 1994): 705713.

477

S. H. Boyle, A. Georgiades, B. H. Brummett, et al., Associations between Central Nervous System Serotonin, Fasting Glucose and Hostility in African American Females. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine 49, no. 1 (2015): 4957.

478

A. Quincozes-Santos, L. D. Bobermin, A. M. de Assis, C. A. Gonçalves, and D. O. Souza, Fluctuations in Glucose Levels Induce Glial Toxicity with Glutamatergic, Oxidative and Inflammatory Implications. Biochimica et Biophysica Acta 1863, no. 1 (Jan. 2017): 114.

479

D. E. Rivera-Aponte, M. P. Méndez-González, A. F. Rivera-Pagán, Y. V. Kucheryavykh, L. Y. Kucheryavykh, S. N. Skatchkov, and M. J. Eaton, Hyperglycemia Reduces Functional Expression of Astrocytic Kir4.1 channels and Glial Glutamate Uptake. Neuroscience 310 (Dec. 2015): 216223.

480

When one brain cell passes a message to another and wants the recipient to become activated or excited. it sends it the chemical messenger glutamate. Glutamate will keep exciting the recipient brain until it is cleared away. If it is not cleared away, the brain cell can die of too much excitation or excitotoxicity. Elevated blood sugar, at levels comparable to those seen in the setting of insulin resistance and diabetes, can interfere with the clearing away of glutamate.

481

G. B. Stefano, S. Challenger, and R. M. Kream, Hyperglycemiaassociated Alterations in Cellular Signaling and Dysregulated Mitochondrial Bioenergetics in Human Metabolic Disorders. European Journal of Nutrition 55, no. 8 (Dec. 2016): 23392345.

482

W. Cai, J. Uribarri, L. Zhu, X. Chen, S. Swamy, Z. Zhao, F. Grosjean, C. Simonaro, G. A. Kuchel, M. Schnaider-Beeri, M. Woodward, G. E. Striker, and H. Vlassara, Oral Glycotoxins Are a Modifiable Cause of Dementia and the Metabolic Syndrome in Mice and Humans. Proceedings of the National Academy of Sciences of the United States of America 111, no. 13 (Apr. 2014): 49404945.

483

K. A. Page, A. Williamson, N. Yu, E. C. McNay, J. Dzuira, R. J. McCrimmon, and R. S. Sherwin, Medium-chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support in Vitro Synaptic Transmission during Acute Hypoglycemia. Diabetes 58, no. 5 (May 2009): 12371244.

484

E. Bullmore and O. Sporns, The Economy of Brain Network Organization. Nature Reviews Neuroscience 13 (2012): 336349.

485

K. Ishibashi, K. Wagatsuma, K. Ishiwata, and K. Ishii, Alteration of the Regional Cerebral Glucose Metabolism in Healthy Subjects by Glucose Loading. Human Brain Mapping 37, no. 8 (Aug. 2016): 28232832.

486

M. Brendel, V. Reinisch, E. Kalinowski, J. Levin, A. Delker, S. Därr, O. Pogarell, S. Förster, P. Bartenstein, and A. Rominger, Hypometabolism in Brain of Cognitively Normal Patients with Depressive Symptoms is Accompanied by Atrophy-Related Partial Volume Effects. Current Alzheimer Research 13, no. 5 (2016): 475486.

487

C. M. Marano, C. I. Workman, C. H. Lyman, E. Kramer, C. R. Hermann, Y. Ma, V. Dhawan, T. Chaly, D. Eidelberg, and G. S. Smith, The Relationship between Fasting Serum Glucose and Cerebral Glucose Metabolism in Late-life Depression and Normal Aging. Psychiatry Research 222, nos. 12 (Apr. 2014): 8490.

488

C. A. Castellano, J. P. Baillargeon, S. Nugent, S. Tremblay, M. Fortier, H. Imbeault, J. Duval, and S. C. Cunnane, Regional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance. PLoS ONE10, no. 12 (Dec. 2015): e0144116.

489

M. Moosavi, N. Naghdi, N. Maghsoudi, and A. S. Zahedi, The Effect of Intrahippocampal Insulin Microinjection on Spatial Learning and Memory. Hormones and Behavior 50 (2006): 748752.

490

D. R. Marks, K. Tucker, M. A. Cavallin, T. G. Mast, and D. A. Fadool, Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors. Journal of Neuroscience 29 (2009): 67346751.

491

C. Benedict, M. Hallschmid, K. Schmitz, B. Schultes, F. Ratter, H. L. Fehm, J. Born, and W. Kern, Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart. Neuropsychopharmacology 32 (2007): 239243.

492

D. Jakubowicz, J. Wainstein, B. Ahrén, Y. Bar-Dayan, Z. Landau, H. R. Rabinovitz, and O. Froy, High-energy Breakfast with Lowenergy Dinner Decreases Overall Daily Hyperglycaemia in Type 2 Diabetic Patients: A Randomised Clinical Trial. Diabetologia 58, no. 5 (May 2015): 912919.

493

D. Jakubowicz, J. Wainstein, B. Ahrén, Z. Landau, Y. Bar-Dayan, and O. Froy, Fasting until Noon Triggers Increased Postprandial Hyperglycemia and Impaired Insulin Response after Lunch and Dinner in Individuals with Type 2 Diabetes: A Randomized Clinical Trial. Diabetes Care 38, no. 10 (Oct. 2015): 18201826.

494

T. Remer and F. Manz, Potential Renal Acid Load of Foods and Its Influence on Urine pH. Journal of the American Dietetic Association 95, no. 7 (Jul. 1995): 791797.

495

R. S. Williams, L. K. Heilbronn, D. L. Chen, A. C. Coster, J. R. Greenfield, and D. Samocha-Bonet, Dietary Acid Load, Metabolic Acidosis and Insulin Resistance Lessons from Cross-sectional and Overfeeding Studies in Humans. Clinical Nutrition 35, no. 5 (Oct. 2016): 10841090.

496

J. Koska, M. K. Ozias, J. Deer, J. Kurtz, A. D. Salbe, S. M. Harman, and P. D. Reaven, A Human Model of Dietary Saturated Fatty Acid Induced Insulin Resistance. Metabolism 65, no. 11 (Nov. 2016): 16211628.

497

P. Kiilerich, L. S. Myrmel, E. Fjære, Q. Hao, F. Hugenholtz, S. B. Sonne, M. Derrien, L. M. Pedersen, R. K. Petersen, A. Mortensen, T. R. Licht, M. U. Rømer, U. B. Vogel, L. J. Waagbø, N. Giallourou, Q. Feng, L. Xiao, C. Liu, B. Liaset, M. Kleerebezem, J. Wang, L. Madsen, and K. Kristiansen, Effect of a Long-term High-protein Diet on Survival, Obesity Development, and Gut Microbiota in Mice. American Journal of Physiology Endocrinology and Metabolism 310, no. 11 (Jun. 2016): E886899.

498

L. K. Stenman, R. Holma, A. Eggert, and R. Korpela, A Novel Mechanism for Gut Barrier Dysfunction by Dietary Fat: Epithelial Disruption by Hydrophobic Bile Acids. American Journal of Physiology: Gastrointestinal and Liver Physiology 304, no. 3 (Feb. 2013): G227234.

499

V. Costarelli and T. A. Sanders, Acute Effects of Dietary Fat Composition on Postprandial Plasma Bile Acid and Cholecystokinin Concentrations in Healthy Premenopausal Women. British Journal of Nutrition 86, no. 4 (Oct. 2001): 471477.

500

C. Ferreira-Pêgo, N. Babio, M. Bes-Rastrollo, D. Corella, R. Estruch, E. Ros, M. Fitó, L. Serra-Majem, F. Arós, M. Fiol, J. M. Santos-Lozano, C. Muñoz-Bravo, X. Pintó, M. Ruiz-Canela, and J. Salas-Salvadó, Frequent Consumption of Sugarand Artificially Sweetened Beverages and Natural and Bottled Fruit Juices Is Associated with an Increased Risk of Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Disease Risk. Journal of Nutrition 146, no. 8 (Aug. 2016): 15281536.

501

M. S. Kim, S. A. Krawczyk, L. Doridot, A. J. Fowler, J. X. Wang, S. A. Trauger, H. L. Noh, H. J. Kang, J. K. Meissen, M. Blatnik, J. K. Kim, M. Lai, and M. A. Herman, ChREBP Regulates Fructoseinduced Glucose Production Independently of Insulin Signaling. Journal of Clinical Investigation 126, no. 11 (Sept. 2016): 43724386.

502

S. E. la Fleur, M. C. Luijendijk, A. J. van Rozen, A. Kalsbeek, and R. Adan, A Free-choice High-fat High-sugar Diet Induces Glucose Intolerance and Insulin Unresponsiveness to a Glucose Load Not Explained by Obesity. International Journal of Obesity 35, no. 4 (Apr. 2011): 595604.

503

S. Lindeberg, M. Eliasson, B. Lindahl, and B. Ahrén, Low Serum Insulin in Traditional Pacific Islanders the Kitava Study. Metabolism 48, no. 10 (Oct. 1999): 12161219.

504

S. Geng, W. Zhu, C. Xie, X. Li, J. Wu, Z. Liang, W. Xie, J. Zhu, Huang, M. Zhu, R. Wu, and C. Zhong, Medium-chain Triglyceride Ameliorates Insulin Resistance and Inflammation in High Fat Diet-induced Obese Mice. European Journal of Nutrition 55, no. 3 (Apr. 2016): 931940.

505

M. Sakurai, K. Nakamura, K. Miura, T. Takamura, K. Yoshita, S. Y. Nagasawa, Y. Morikawa, M. Ishizaki, T. Kido, Y. Naruse, M. Nakashima, K. Nogawa, Y. Suwazono, S. Sasaki, and H. Nakagawa, Dietary Carbohydrate Intake, Presence of Obesity and the Incident Risk of Type 2 Diabetes in Japanese Men. Journal of Diabetes Investigation 7, no. 3 (May 2016): 343351.

506

P. J. Lin and K. T. Borer, Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. PLoS ONE11, no. 10 (Oct. 2016): e0165378.

507

R. Salvia, S. DAmore, G. Graziano, C. Capobianco, M. Sangineto, Paparella, P. de Bonfils, G. Palasciano, and M. Vacca, Shortterm Benefits of an Unrestricted-calorie Traditional Mediterranean Diet, Modified with a Reduced Consumption of Carbohydrates at Evening, in Overweight-obese Patients. International Journal of Food Sciences and Nutrition 68, no. 2 (Mar. 2017): 234248.

508

C. Eelderink, M. W. Noort, N. Sozer, M. Koehorst, J. J. Holst, C. F. Deacon, J. F. Rehfeld, K. Poutanen, R. J. Vonk, L. Oudhuis, and M. G. Priebe, The Structure of Wheat Bread Influences the Postprandial Metabolic Response in Healthy Men. Food & Function 6, no. 10 (Oct. 2015): 32363248.

509

K. S. Juntunen, D. E. Laaksonen, K. Autio, L. K. Niskanen, J. J. Holst, K. E. Savolainen, K. H. Liukkonen, K. S. Poutanen, and H. M. Mykkänen, Structural Differences between Rye and Wheat Breads but Not Total Fiber Content May Explain the Lower Postprandial Insulin Response to Rye Bread. American Journal of Clinical Nutrition 78, no. 5 (Nov. 2003): 957964.

510

S. Sonia, F. Witjaksono, and R. Ridwan, Effect of Cooling of Cooked White Rice on Resistant Starch Content and Glycemic Response. Asia Pacific Journal of Clinical Nutrition 24, no. 4 (2015): 620625.

511

Joint WHO/FAO/UNU Expert Consultation, Protein and Amino Acid Requirements in Human Nutrition. World Health Organ Technical Report Series 935 (2007): 1265, back cover.

512

I. Sluijs, J. W. Beulens, D. L. van der A, A. M. Spijkerman, D. E. Grobbee, and Y. T. van der Schouw, Dietary Intake of Total, Animal, and Vegetable Protein and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL Study. Diabetes Care 33, no. 1 (Jan. 2010): 4348.

513

J. Matta, N. Mayo, I. J. Dionne, P. Gaudreau, T. Fulop, D. Tessier, K. Gray-Donald, B. Shatenstein, and J. A. Morais, Muscle Mass Index and Animal Source of Dietary Protein Are Positively Associated with Insulin Resistance in Participants of the NuAge Study. Journal of Nutrition Health & Aging 20, no. 2 (Feb. 2016): 9097.

514

G. I. Smith, J. Yoshino, K. L. Stromsdorfer, S. J. Klein, F. Magkos, D. N. Reeds, S. Klein, and B. Mittendorfer, Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation. Diabetes 64, no. 5 (May 2015): 15551563.

515

G. I. Smith, J. Yoshino, S. C. Kelly, D. N. Reeds, A. Okunade, B. W. Patterson, S. Klein, and B. Mittendorfer, High-protein Intake during Weight Loss Therapy Eliminates the Weight-loss-induced Improvement in Insulin Action in Obese Postmenopausal Women. Cell Reports 17, no. 3 (Oct. 2016): 849861.

516

D. Aune, G. Ursin, and M. B. Veierød, Meat Consumption and the Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis of Cohort Studies. Diabetologia 52, no. 11 (Nov. 2009): 22772287, doi: 10.1007/s00125-009-1481-x.

517

N. Benaicheta, F. Z. Labbaci, M. Bouchenak, and F. O. Boukortt, Effect of Sardine Proteins on Hyperglycaemia, Hyperlipidaemia and Lecithin: Cholesterol Acyltransferase Activity, in High-Fat DietInduced Type 2 Diabetic Rats. British Journal of Nutrition 115, no. 1 (Jan. 2016): 613.

518

M. S. Ottum and A. M. Mistry, Advanced Glycation End-products: Modifiable Environmental Factors Profoundly Mediate Insulin Resistance. Journal of Clinical Biochemistry and Nutrition 57, no. 1 (Jul. 2015): 112.

519

A. Taniguchi-Fukatsu, H. Yamanaka-Okumura, Y. Naniwa-Kuroki, Y. Nishida, H. Yamamoto, Y. Taketani, and E. Takeda, Natto and Viscous Vegetables in a Japanese-style Breakfast Improved Insulin Sensitivity, Lipid Metabolism and Oxidative Stress in Overweight Subjects with Impaired Glucose Tolerance. British Journal of Nutrition 107, no. 8 (Apr. 2012): 11841191.

520

P. Ebeling, H. Yki-Järvinen, A. Aro, et al., Glucose and Lipid Metabolism and Insulin Sensitivity in Type 1 Diabetes: The Effect of Guar Gum. American Journal of Clinical Nutrition 48, no. 1 (1988): 98103.

521

C. A. Clark, J. Gardiner, M. I. McBurney, S. Anderson, L. J. Weatherspoon, D. N. Henry, and N. G. Hord, Effects of Breakfast Meal Composition on Second Meal Metabolic Responses in Adults with Type 2 Diabetes mellitus. European Journal of Clinical Nutrition 60, no. 9 (Sept. 2006): 11221129.

522

M. Drehmer, M. A. Pereira, M. I. Schmidt, B. Del Carmen, M. Molina, S. Alvim, P. A. Lotufo, and B. B. Duncan, Associations of Dairy Intake with Glycemia and Insulinemia, Independent of Obesity, in Brazilian Adults: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). American Journal of Clinical Nutrition 101, no. 4 (Apr. 2015): 775782.

523

M. Chen, Q. Sun, E. Giovannucci, D. Mozaffarian, J. E. Manson, W. C. Willett, and F. B. Hu, Dairy Consumption and Risk of Type 2 Diabetes: 3 Cohorts of US Adults and an Updated Meta-analysis. BMC Medicine 12 (Nov. 2014): 215.

524

C. J. Hulston, A. A. Churnside, and M. C. Venables, Probiotic Supplementation Prevents High-fat, Overfeeding-induced Insulin Resistance in Human Subjects. British Journal of Nutrition 113, no. 4 (Feb. 2015): 596602.

525

Mohamadshahi et al., Effects of Probiotic Yogurt Consumption on Inflammatory Biomarkers in Patients with Type 2 Diabetes. 8388.

526

J. Dolpady, C. Sorini, C. Di Pietro, I. Cosorich, R. Ferrarese, D. Saita, M. Clementi, F. Canducci, and M. Falcone, Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment. Journal of Diabetes Research 2016 (2016): 7569431.

527

Z. Ghorbani, A. Hekmatdoost, and P. Mirmiran, Anti-hyperglycemic and Insulin Sensitizer Effects of Turmeric and Its Principle [sic] Constituent Curcumin. International Journal of Endocrinology and Metabolism 12, no. 4 (Oct. 2014): e18081.

528

C. K. Atal, R. K. Dubey, and J. Singh, Biochemical Basis of Enhanced Drug Bioavailability by Piperine: Evidence That Piperine Is a Potent Inhibitor of Drug Metabolism. Journal of Pharmacology and Experimental Therapeutics 232, no. 1 (Jan. 1985): 258262.

529

G. Shoba, D. Joy, T. Joseph, M. Majeed, R. Rajendran, and P. S. Srinivas, Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Medica 64, no. 4 (May 1998): 353356.

530

P. Anand, A. B. Kunnumakkara, R. A. Newman, and B. B. Aggarwal, Bioavailability of Curcumin: Problems and Promises. Molecular Pharmaceutics 4, no. 6 (2007): 807818.

531

S. Prasad, A. K. Tyagi, and B. B. Aggarwal, Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: The Golden Pigment from Golden Spice. Cancer Research and Treatment: Official Journal of Korean Cancer Association 46, no. 1 (2014): 218.

532

A. S. Sahib, Anti-diabetic and Antioxidant Effect of Cinnamon in Poorly Controlled Type-2 Diabetic Iraqi Patients: A Randomized, Placebo-controlled Clinical Trial. Journal of Intercultural Ethnopharmacology 5, no. 2 (Feb. 2016): 108113.

533

J. Hlebowicz, A. Hlebowicz, S. Lindstedt, O. Björgell, P. Höglund, J. J. Holst, G. Darwiche, and L. O. Almér, Effects of 1 and 3 g Cinnamon on Gastric Emptying, Satiety, and Postprandial Blood Glucose, Insulin, Glucose-dependent Insulinotropic Polypeptide, Glucagon-like Peptide 1, and Ghrelin Concentrations in Healthy Subjects. American Journal of Clinical Nutrition 89, no. 3 (Mar. 2009): 815821.

534

N. Veronese, S. F. Watutantrige, C. Luchini, M. Solmi, G. Sartore, G. Sergi, E. Manzato, M. Barbagallo, S. Maggi, and B. Stubbs, Effect of Magnesium Supplementation on Glucose Metabolism in People with or at Risk of Diabetes: A Systematic Review and Meta-analysis of Double-blind Randomized Controlled Trials. European Journal of Clinical Nutrition 70, no. 12 (Dec. 2016): 13541359.

535

https://www.cedars-sinai.edu/Patients/Programs-and-Services/Documents/CP0403MagnesiumRichFoods.pdf.

536

B. R. Stephens, K. Granados, T. W. Zderic, et al., Effects of 1 Day of Inactivity on Insulin Action in Healthy Men and Women: Interaction with Energy Intake. Metabolism 60 (2011): 941949.

537

M. S. Lunde, V. T. Hjellset, and A. T. Hostmark, Slow Post Meal Walking Reduces the Blood Glucose Response: An Exploratory Study in Female Pakistani Immigrants. Journal of Immigrant and Minority Health 14 (2012): 816822.

538

H. Nygaard, S. E. Tomten, and A. T. Hostmark, Slow Postmeal Walking Reduces Postprandial Glycemia in Middle-aged Women. Applied Physiology, Nutrition, and Metabolism 34 (2009): 10871092.

539

J. Henson, M. J. Davies, D. H. Bodicoat, et al., Breaking up Prolonged Sitting with Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study. Diabetes Care 39 (2016): 130138.

540

P. C. Dempsey, R. N. Larsen, P. Sethi, et al., Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting with Brief Bouts of Light Walking or Simple Resistance Activities. Diabetes Care 39 (2016): 964972.

541

, , . . .

542

S. F. Chastin, T. Egerton, C. Leask, et al., Meta-analysis of the Relationship between Breaks in Sedentary Behavior and Cardiometabolic Health. Obesity 23 (2015): 18001810.

543

E. Chacko, Exercising Tactically for Taming Postmeal Glucose Surges. Scientifica (Cairo) (2016): 4045717.

544

R. J. Manders, J. W. van Dijk, and L. J. van Loon, Low-intensity Exercise Reduces the Prevalence of Hyperglycemia in Type 2 Diabetes. Medicine & Science in Sports & Exercise 42, no. 2 (Feb. 2010): 219225.

545

J. B. Gillen, B. J. Martin, M. J. MacInnis, L. E. Skelly, M. A. Tarnopolsky, and M. J. Gibala, Twelve Weeks of Sprint Interval Training Improves Indices of Cardiometabolic Health Similar to Traditional Endurance Training despite a Five-fold Lower Exercise Volume and Time Commitment. PLoS ONE11, no. 4 (2016): e0154075.

546

C. Benedict et al., Gut Microbiota and Glucometabolic Alterations in Response to Recurrent Partial Sleep Deprivation in Normal-weight Young Individuals. Molecular Metabolism (published online Oct. 24, 2016), http://dx.doi.org/10.1016/j.molmet.2016.10.003.

547

A. J. Graveling, I. J. Deary, and B. M. Frier, Acute Hypoglycemia Impairs Executive Cognitive Function in Adults with and without Type 1 Diabetes. Diabetes Care 36, no. 10 (Oct. 2013): 32403246.

548

K. A. Page, A. Williamson, N. Yu, E. C. McNay, J. Dzuira, R. J. McCrimmon, and R. S. Sherwin, Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support in vitro Synaptic Transmission during Acute Hypoglycemia. Diabetes 58, no. 5 (May 2009): 12371244.

549

Y. Nonaka, T. Takagi, M. Inai, S. Nishimura, S. Urashima, K. Honda, T. Aoyama, and S. Terada, Lauric Acid Stimulates Ketone Body Production in the KT-5 Astrocyte Cell Line. Journal of Oleo Science 65, no. 8 (Aug. 2016): 693699.

550

I. Hu Yang, J. E. De la Rubia Ortí, P. Selvi Sabater, S. Sancho Castillo, M. J. Rochina, N. Manresa Ramón, and I. Montoya-Castilla, Coconut Oil: Non-alternative Drug Treatment against Alzheimers Disease. Nutrición Hospitalaria 32, no. 6 (Dec. 2015): 28222827.

551

A. J. Murray, N. S. Knight, M. A. Cole, L. E. Cochlin, E. Carter, K. Tchabanenko, T. Pichulik, M. K. Gulston, H. J. Atherton, M. A. Schroeder, R. M. Deacon, Y. Kashiwaya, M. T. King, R. Pawlosky, N. Rawlins, D. J. Tyler, J. L. Griffin, J. Robertson, R. L. Veech, and Clarke, Novel Ketone Diet Enhances Physical and Cognitive Performance. FASEB Journal 30, no. 12 (Dec. 2016): 40214032.

552

M. Vijayakumar, D. M. Vasudevan, K. R. Sundaram, S. Krishnan, K. Vaidyanathan, S. Nandakumar, R. Chandrasekhar, and N. Mathew, A Randomized Study of Coconut Oil versus Sunflower Oil on Cardiovascular Risk Factors in Patients with Stable Coronary Heart Disease. Indian Heart Journal 68, no. 4 (Jul. Aug. 2016): 498506.

553

D. A. Cardoso, A. S. Moreira, G. M. de Oliveira, R. Raggio Luiz, and G. Rosa, A Coconut Extra Virgin Oil-Rich Diet Increases HDL Cholesterol and Decreases Waist Circumference and Body Mass in Coronary Artery Disease Patients. Nutricion Hospitalaria 32, no. 5 (Nov. 2015): 21442152.

554

J. K. Kiecolt-Glaser, M. A. Belury, R. Andridge, W. B. Malarkey, and R. Glaser, Omega-3 Supplementation Lowers Inflammation and Anxiety in Medical Students: A Randomized Controlled Trial. Brain, Behavior, and Immunity 25, no. 8 (Nov. 2011): 17251734.

555

R. Narendran, W. G. Frankle, N. S. Mason, M. F. Muldoon, and B. Moghaddam, Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation. ed. B. Le Foll, PLoS ONE7, no. 10 (2012): e46832.

556

J. Bradbury, S. P. Myers, and C. Oliver, An Adaptogenic Role for Omega-3 Fatty Acids in Stress; a Randomised Placebo Controlled Double Blind Intervention Study. Nutrition Journal 3 (2004): 20.

557

L. D. Lawson and B. G. Hughes, Absorption of Eicosapentaenoic Acid and Docosahexaenoic Acid from Fish Oil Triacylglycerols or Fish Oil Ethyl Esters Co-ingested with a High-fat Meal. Biochemical and Biophysical Research Communications 156, no. 2 (Oct. 1988): 960963.

558

X. Liu and T. Osawa, Astaxanthin Protects Neuronal Cells against Oxidative Damage and Is a Potent Candidate for Brain Food. Forum of Nutrition 61 (2009): 129135.

559

F. Shahidi and Y. Zhong, Lipid Oxidation and Improving the Oxidative Stability. Chemical Society Reviews 39, no. 11 (Nov. 2010): 40674079.

560

B. B. Albert, J. G. Derraik, D. Cameron-Smith, P. L. Hofman, S. Tumanov, S. G. Villas-Boas, M. L. Garg, and W. S. Cutfield, Fish Oil Supplements in New Zealand Are Highly Oxidised and Do Not Meet Label Content of n-3 PUFA. Scientific Reports 5 (Jan. 2015): 7928.

561

M. Maes, R. Smith, A. Christophe, E. Vandoolaeghe, A. van Gastel, H. Neels, P. Demedts, A. Wauters, and H. Y. Meltzer, Lower Serum High-density Lipoprotein Cholesterol (HDLC) in Major Depression and in Depressed Men with Serious Suicidal Attempts: Relationship with Immune-inflammatory Markers. Acta Psychiatrica Scandinavica 95, no. 3 (Mar. 1997): 212221.

562

M. F. Muldoon, S. B. Manuck, and K. A. Matthews, Lowering Cholesterol Concentrations and Mortality: A Quantitative Review of Primary Prevention Trials. British Medical Journal 301, no. 6747 (Aug. 1990): 309314.

563

A. Gabriel, Changes in Plasma Cholesterol in Mood Disorder Patients: Does Treatment Make a Difference?. Journal of Affective Disorders 99, nos. 13 (Apr. 2007): 273278.

564

A. S. Wells, N. W. Read, J. D. Laugharne, and N. S. Ahluwalia, Alterations in Mood after Changing to a Low-fat Diet. British Journal of Nutrition 79, no. 1 (Jan. 1998): 2330.

565

L. Velázquez-López, A. V. Muñoz-Torres, C. García-Peña, M. López-Alarcón, S. Islas-Andrade, and J. Escobedo de la Peña, Fiber in Diet Is Associated with Improvement of Glycated Hemoglobin and Lipid Profile in Mexican Patients with Type 2 Diabetes. Journal of Diabetes Research 2016 (2016): 2980406.

566

H. E. Anderson-Vasquez, P. Pérez-Martínez, P. Ortega Fernández, and C. Wanden-Berghe, Impact of the Consumption of a Rich Diet in Butter and it [sic] Replacement for a Rich Diet in Extra Virgin Olive Oil on Anthropometric, Metabolic and Lipid Profile in Postmenopausal Women. Nutrición Hospitalaria 31, no. 6 (Jun. 2015): 25612570.

567

C. L. Kien, J. Y. Bunn, R. Stevens, J. Bain, O. Ikayeva, K. Crain, T. R. Koves, and D. M. Muoio, Dietary Intake of Palmitate and Oleate Has Broad Impact on Systemic and Tissue Lipid Profiles in Humans. American Journal of Clinical Nutrition 99, no. 3 (Mar. 2014): 436445.

568

Cardoso et al., A Coconut Extra Virgin Oil-Rich Diet Increases HDL Cholesterol and Decreases Waist Circumference and Body Mass in Coronary Artery Disease Patients. 21442152.

569

R. P. Mensink, P. L. Zock, A. D. Kester, and M. B. Katan, Effects of Dietary Fatty Acids and Carbohydrates on the Ratio of Serum Total to HDL Cholesterol and on Serum Lipids and Apolipoproteins: A Meta-analysis of 6 Controlled Trials. American Journal of Clinical Nutrition 77, no. 5 (May 2003): 11461155.

570

E. H. Temme, R. P. Mensink, and G. Hornstra, Comparison of the Effects of Diets Enriched in Lauric, Palmitic, or Oleic Acids on Serum Lipids and Lipoproteins in Healthy Women and Men. American Journal of Clinical Nutrition 63, no. 6 (Jun. 1996): 897903.

571

N. B. Cater, H. J. Heller, and M. A. Denke, Comparison of the Effects of Medium-chain Triacylglycerols, Palm Oil, and High Oleic Acid Sunflower Oil on Plasma Triacylglycerol Fatty Acids and Lipid and Lipoprotein Concentrations in Humans. American Journal of Clinical Nutrition 65, no. 1 (Jan. 1997): 4145.

572

C. Stough, A. Scholey, J. Lloyd, J. Spong, S. Myers, and L. A. Downey, The Effect of 90 day Administration of a High Dose Vitamin B-complex on Work Stress. Human Psychopharmacology 26, no. 7 (Oct. 2011): 470476.

573

A. Pipingas, D. A. Camfield, C. Stough, A. B. Scholey, K. H. Cox, D. White, J. Sarris, A. Sali, and H. Macpherson, Effects of Multivitamin, Mineral and Herbal Supplement on Cognition in Younger Adults and the Contribution of B Group Vitamins. Human Psychopharmacology 29, no. 1 (Jan. 2014): 7382.

574

O. P. Almeida, A. H. Ford, V. Hirani, V. Singh, F. M. van Bockxmeer, K. McCaul, and L. Flicker, B Vitamins to Enhance Treatment Response to Antidepressants in Middle-aged and Older Adults: Results from the B-VITAGE Randomised, Double-blind, Placebocontrolled Trial. British Journal of Psychiatry 205, no. 6 (Dec. 2014): 450457.

575

O. P. Almeida, K. Marsh, H. Alfonso, L. Flicker, T. M. Davis, and G. J. Hankey, B-vitamins Reduce the Long-term Risk of Depression after Stroke: The VITATOPS-DEP Trial. Annals of Neurology 68, no. 4 (Oct. 2010): 503510.

576

D. O. Kennedy, R. Veasey, A. Watson, F. Dodd, E. Jones, S. Maggini, and C. F. Haskell, Effects of High-dose B Vitamin Complex with Vitamin C and Minerals on Subjective Mood and Performance in Healthy Males. Psychopharmacology 211, no. 1 (Jul. 2010): 5568.

577

O. Stanger, B. Fowler, K. Piertzik, M. Huemer, E. Haschke-Becher, Semmler, et al., Homocysteine, Folate and Vitamin B12 in Neuropsychiatric Diseases: Review and Treatment Recommendations. Expert Review of Neurotherapeutics 9 (2009): 13931412.

578

K. Yoshino, M. Nishide, T. Sankai, M. Inagawa, K. Yokota, Y. Moriyama, et al., Validity of Brief Food Frequency Questionnaire for Estimation of Dietary Intakes of Folate, Vitamins B6 and B12 and Their Associations with Plasma Homocysteine Concentrations. International Journal of Food Sciences and Nutrition 61 (2010): 6167.

579

A. Oulhaj, F. Jernerén, H. Refsum, A. D. Smith, and C. A. de Jager, Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. Journal of Alzheimers Disease 50, no. 2 (Jan. 2016): 547557.

580

M. Montava, S. Garcia, J. Mancini, Y. Jammes, J. Courageot, J. P. Lavieille, and F. Feron, Vitamin D3 Potentiates Myelination and Recovery after Facial Nerve Injury. European Archives of OtoRhino-Laryngology 272, no. 10 (Oct. 2014): 28152823.

581

J. F. Chabas, D. Stephan, T. Marqueste, S. Garcia, M. N. Lavaut, C. Nguyen, R. Legre, M. Khrestchatisky, P. Decherchi, and F. Feron, Cholecalciferol (Vitamin D3) Improves Myelination and Recovery after Nerve Injury. PLoS ONE8, no. 5 (May 2013): e65034.

582

O. Józefowicz, J. Rabe-Jabłońska, A. Woźniacka, and D. Strzelecki, Analysis of Vitamin D Status in Major Depression. Journal of Psychiatric Practice 20, no. 5 (Sept. 2014): 329337.

583

C. Grudet, J. Malm, A. Westrin, and L. Brundin, Suicidal Patients Are Deficient in Vitamin D, Associated with a Pro-inflammatory Status in the Blood. Psychoneuroendocrinology 5 C (Sept. 2014): 210219.

584

R. Ramadan, V. Vaccarino, F. Esteves, D. S. Sheps, J. D. Bremner, P. Raggi, and A. A. Quyyumi, Association of Vitamin D Status with Mental Stress-induced Myocardial Ischemia in Patients with Coronary Artery Disease. Psychosomatic Medicine 76, no. 7 (Sept. 2014): 569575.

585

A. Gholamrezaei, Z. S. Bonakdar, L. Mirbagher, and N. Hosseini, Sleep Disorders in Systemic Lupus Erythematosus. Does Vitamin D Play a Role? Lupus 23, no. 10 (Sept. 2014): 10541058.

586

V. K. Wilson, D. K. Houston, L. Kilpatrick, J. Lovato, K. Yaffe, J. A. Cauley, T. B. Harris, E. M. Simonsick, H. N. Ayonayon, S. B. Kritchevsky, and K. M. Sink, Health, Aging and Body Composition Study. Relationship between 25-Hydroxyvitamin D and Cognitive Function in Older Adults: The Health, Aging and Body Composition Study. Journal of the American Geriatrics Society 62, no. 4 (Apr. 2014): 636641.

587

A. L. Peterson, C. Murchison, C. Zabetian, J. B. Leverenz, G. S. Watson, T. Montine, N. Carney, G. L. Bowman, K. Edwards, and J. F. Quinn, Memory, Mood, and Vitamin D in Persons with Parkinsons Disease. Journal of Parkinsons Disease 3, no. 4 (2013): 547555.

588

D. E. Bredesen, Reversal of Cognitive Decline: A Novel Therapeutic Program. Aging 6, no. 9 (2014): 707717.

589

L. Matsuoka, L. Ide, J. Wortsman, J. MacLaughlin, and M. F. Holick, Sunscreens Suppress Cutaneous Vitamin D3 Synthesis. Journal of Clinical Endocrinology & Metabolism 64 (1987): 11651168.

590

K. S. Kendler, J. M. Hettema, F. Butera, C. O. Gardner, and C. A. Prescott, Life Event Dimensions of Loss, Humiliation, Entrapment, and Danger in the Prediction of Onsets of Major Depression and Generalized Anxiety. Archives of General Psychiatry 60 (2003): 789796.

591

F. Grabenhorst and E. T. Rolls, Value, Pleasure and Choice in the Ventral Prefrontal Cortex. Trends in Cognitive Sciences 15 (2011): 5667.

592

M. G. Craske, A. E. Meuret, T. Ritz, M. Treanor, and H. J. Dour, Treatment for Anhedonia: A Neuroscience Driven Approach. Depression and Anxiety 33, no. 10 (Oct. 2016): 927938.

593

S. Dalm, E. R. de Kloet, and M. S. Oitzl, Post-training Reward Partially Restores Chronic Stress Induced Effects in Mice. ed. G. Chapouthier, PLoS ONE7, no. 6 (2012): e39033.

594

N. Geschwind, F. Peeters, N. Jacobs, P. Delespaul, C. Derom, E. Thiery, J. van Os, and M. Wichers, Meeting Risk with Resilience: High Daily Life Reward Experience Preserves Mental Health. Acta Psychiatrica Scandinavica 122, no. 2 (Aug. 2010): 129138.

595

G. S. Alexopoulos and P. Arean, A Model for Streamlining Psychotherapy in the RdoC Era: The Example of Engage, Molecular Psychiatry 19, no. 1 (Jan. 2014): 1419.

596

. . . .: , , 2018.

597

D. Becker and J. van der Pligt, Forcing Your Luck: Goal-striving Behavior in Chance Situations. Motivation and Emotion 40 (2016): 203211.

598

M. Lehne and S. Koelsch, Toward a General Psychological Model of Tension and Suspense. Frontiers in Psychology 6 (2015): 79.

599

S. H. Kim, Y. H. Kim, and H. J. Kim, Laughter and Stress Relief in Cancer Patients: A Pilot Study. Evidence-Based Complementary and Alternative Medicine 2015 (2015): 864739.

600

K. Hayashi, I. Kawachi, T. Ohira, K. Kondo, K. Shirai, and N. Kondo, Laughter is the Best Medicine? A Cross-Sectional Study of Cardiovascular Disease Among Older Japanese Adults. Journal of Epidemiology 26, no. 10 (Oct. 2016): 546552.

601

A. J. Blood, R. J. Zatorre, P. Bermudez, and A. C. Evans, Emotional Responses to Pleasant and Unpleasant Music Correlate with Activity in Paralimbic Brain Regions. Nature Neuroscience 2 (1999): 382387.

602

H. G. MacDougall and S. T. Moore, Marching to the Beat of the Same Drummer: The Spontaneous Tempo of Human Locomotion. Journal of Applied Physiology 99 (2005): 11641173.

603

D. Moelants, Preferred Tempo Reconsidered. in Proceedings of the 7th International Conference on Music Perception and Cognition, eds. C. Stevens, D. Burnham, G. McPherson, E. Schubert, and J. Renwick (Adelaide, South Australia: Causal Production, 2002), 580583.

604

C. J. Bacon, T. R. Myers, and C. I. Karageorghis, Effect of Musicmovement Synchrony on Exercise Oxygen Consumption. Journal of Sports Medicine and Physical Fitness 52 (2012): 359365.

605

C. I. Karageorghis, P. C. Terry, A. M. Lane, D. T. Bishop, and D. L. Priest, The BASES Expert Statement on Use of Music in Exercise. Journal of Sports Sciences 30, no. 9 (May 2012): 953956.

606

N. Guegen and C. Jacob, The Influence of Music on Temporal Perceptions in an On-hold Waiting Situation. Psychology of Music 30 (2002): 210214.

607

J. Gibbon, R. M. Church, and W. H. Meck, Scalar Timing in Memory. Annals of the New York Academy of Sciences 423 (1984): 5277.

608

S. Droit-Volet, D. Ramos, J. L. Bueno, and E. Bigand, Music, Emotion, and Time Perception: The Influence of Subjective Emotional Valence and Arousal? Frontiers in Psychology 4 (Jul. 2013): 417.

609

A. Nguyen, L. Frobert, I. McCluskey, P. Golay, C. Bonsack, and J. Favrod, Development of the Positive Emotions Program for Schizophrenia: An Intervention to Improve Pleasure and Motivation in Schizophrenia. Frontiers in Psychiatry 7 (Feb. 2016): 13.

610

G. F. Koob, Addiction is a Reward Deficit and Stress Surfeit Disorder. Frontiers in Psychiatry 4 (Aug. 2013): 72.

611

T. S. Shippenberg, A. Zapata, and V. I. Chefer, Dynorphin and the Pathophysiology of Drug Addiction. Pharmacology & Therapeutics 116, no. 2 (Nov. 2007): 306321.

612

G. L. Shulman, J. A. Fiez, M. Corbetta, R. L. Buckner, F. M. Miezin, et al., Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex. Journal of Cognitive Neuroscience 9 (1997): 648663.

613

M. E. Raichle, A. M. MacLeod, A. Z. Snyder, W. J. Powers, D. A. Gusnard, and G. L. Shulman, A Default Mode of Brain Function. PNAS98 (2001): 676682.

614

R. L. Carhart-Harris and K. J. Friston, The Default-mode, Egofunctions and Free-energy: A Neurobiological Account of Freudian Ideas. Brain 133, no. 4 (2010): 12651283.

615

TED (. technology, entertainment, design; , , ) , , .

616

M. Kent, C. T. Rivers, and G. Wrenn, Goal-directed Resilience in Training (GRIT): A Biopsychosocial Model of Self-regulation, Executive Functions, and Personal Growth (Eudaimonia) in Evocative Contextsof PTSD, Obesity, and Chronic Pain. Behavioral Sciences 5, no. 2 (Jun. 2015): 264304.

617

http://www.venchar.com/2005/01/the_stockdale_p.html.

618

A. Bandura, Self-efficacy: The Exercise of Control (New York: Freeman, 1997).

619

K. Simmen-Janevska, V. Brandstätter, and A. Maercker, The Overlooked Relationship between Motivational Abilities and Posttraumatic Stress: A Review. European Journal of Psychotraumatology 3 (2012): doi: 10.3402/ejpt.v3i0.18560.

620

. . . .: , , 2013.

621

A. Diedrich, S. G. Hofmann, P. Cuijpers, and M. Berking, Selfcompassion Enhances the Efficacy of Explicit Cognitive Reappraisal as an Emotional Regulation Strategy in Individuals with Major Depressive Disorder. Behaviour Research and Therapy 82 (Jul. 2016): 110.

622

B. M. Iacoviello and D. S. Charney, Psychosocial Facets of Resilience: Implications for Preventing Posttrauma Psychopathology, Treating Trauma Survivors, and Enhancing Community Resilience. European Journal of Psychotraumatology 5 (Oct. 2014): 10.3402/ejpt.v5.23970.

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