Мусорная ДНК. Путешествие в темную материю генома - читать онлайн книгу. Автор: Несса Кэри cтр.№ 79

8. Полезное обсуждение проблемы см. в: Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012 Oct; 13(10):693-704.

9. Полезный обзор см. в: Armanios М, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012 Oct; 13(10):693-704.

10. Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet. 1996;18(2):173-9.

11. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994 Dec 23;266(5193):2011-5.

12. http://www.nlm.nih.gov/medlineplus/ency/anatomyvideos/000104.htm.

13. Chiu CP, Dragowska W, Kim NW, Vaziri H, Yui J, Thomas ТЕ, Harley CB, Lansdorp PM. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone. Stem Cells. 1996 Mar; 14(2):239-48.

14. Vaziri H, Dragowska W, Allsopp RC, Thomas ТЕ, Harley CB, Lansdorp PM. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Set USA. 1994 Oct ll;91(21):9857-60.

15. Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012 Oct; 13(10):693-704.

16. Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012 Oct; 13(10):693-704.

17. Отличное клиническое описание и полезные иллюстрации см. в: Calado RT, Young NS. Telomere diseases. N Engl J Med. 2009 Dec 10;361(24):2353-65.

18. Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, Vulto I, Xie M, Qi X, Tuder RM, Phillips JA 3rd, Lansdorp PM, Loyd JE, Armanios MY. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci USA. 2008 Sep 2;105(35):13051-6.

19. Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, Lawson WE, Xie M, Vulto I, Phillips JA 3rd, Lansdorp PM, Greider CW, Loyd JE. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007 Mar 29;356(13):1317-26.

20. Tsakiri KD,CronkhiteJT, Kuan PJ, XingC, RaghuG, Weissler JC, Rosenblatt RL, Shay JW, Garcia CK. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sei USA. 2007 May 1;104(18):7552-7.

21. Cronkhite JT, Xing C, Raghu G, Chin KM, Torres F, Rosenblatt RL, Garcia CK. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med. 2008 Oct 1;178(7):729-37.

22. Полезное описание см. в: see http://www.patient.co.uk/doctor/aplastic-anaemia.

23. de la Fuente J, Dokal I. Dyskeratosis congenita: advances in the understanding of the telomerase defect and the role of stem cell transplantation. Pediatr Transplant. 2007 Sep; 11(6):584-94.

24. Armanios M, Chen JL, Chang YP, Brodsky RA, Hawkins A, Griffin CA, Eshleman JR, Cohen AR, Chakravarti A, Hamosh A, Greider CW. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci USA. 2005 Nov 1;102(44):15960-4.

25. http://www.who.int/mediacentre/factsheets/fs339/en.

26. Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med. 2011 Oct 15;184(8):904-12.

27. Цит. no: Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010 Mar 25;464(7288):520-528.

28. Статистика дается по данным American Heart Association on Older Americans & Cardiovascular Diseases (Американской ассоциации изучения сердца пожилых американцев и сердечно-сосудистых заболеваний), 2013.

29. http://www.rcpsych.ac.uk/healthadvice/problemsdisorders/depressioninolderadults.aspx.

30. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005 Aug 20-26;366(9486):662-4.

31. Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003 Feb 1;361(9355):393-5.

32. Fitzpatrick AL, Kronmal RA, Kimura M, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Hardikar S, Aviv A. Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci MedSci. 2011 Apr; 66<4):421-9.

33. Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci USA. 2010 Jan 26;107 Suppl 1:1710-7.

34. Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004 Jul; 130(4):601-30.

35. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA. 2004 Dec 7; 101(49): 17312-5.

36. http://www.who.int/mediacentre/factsheets/fs311/en/index.html.

37. Полезное введение в эту область см. в: Tennen RI, Chua KF. Chromatin regulation and genome maintenance by mammalian SIRT6. Trends Biochem Sci. 2011 Jan; 36(l):39-46.

38. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005 Aug 20-26;366(9486):662-4.

39. UNFPA report on Ageing in The Twenty-First Century (Доклад Фонда ООН в области народонаселения «Старение в XXI веке»), 2012.

40. Jennings BJ, Ozanne SE, Dorling MW, Hales CN. Early growth determines longevity in male rats and may be related to telomere shortening in the kidney. FEBS Lett. 1999 Apr 1;448(1):4-8.

Глава 6

1. Из: The King and I («Король и я»), 1956, автор сценария Ernest Lehman, 20th Century Fox.

2. Хороший обзор типов центромер различных ветвей эволюционного древа см. в: Ogiyama Y, Ishii К. The smooth and stable operation of centromeres. Genes Genet Syst. 2012;87(2):63-73.